Outputs (7)

MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation (2024)
Journal Article
Al Saihati, H. A., Dessouky, A. A., Salim, R. F., Elgohary, I., El-Sherbiny, M., Ali, F. E. M., Moustafa, M. M. A., Shaheen, D., Forsyth, N. R., Badr, O. A., & Ebrahim, N. (in press). MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation. Stem Cell Research and Therapy, 15(1), 1-22. https://doi.org/10.1186/s13287-024-03889-9

Background: Coronavirus disease 2019 (COVID-19) has created a global pandemic with significant morbidity and mortality. SARS-CoV-2 primarily infects the lungs and is associated with various organ complications. Therapeutic approaches to combat COVID-... Read More about MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation.

A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration. (2024)
Journal Article
Younus, Z. M., Ahmed, I., Roach, P., & Forsyth, N. R. (in press). A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration. Biomaterials and Biosystems, 15, Article 100099. https://doi.org/10.1016/j.bbiosy.2024.100099

The bone-cartilage interface is defined by a unique arrangement of cells and tissue matrix. Injury to the interface can contribute to the development of arthritic joint disease. Attempts to repair osteochondral damage through clinical trials have gen... Read More about A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration..

Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. (2024)
Journal Article
Ebrahim, N., Al Saihati, H. A., Alali, Z., Aleniz, F. Q., Mahmoud, S. Y. M., Badr, O. A., Dessouky, A. A., Mostafa, O., Hussien, N. I., Farid, A. S., El-Sherbiny, M., Salim, R. F., Forsyth, N. R., Ali, F. E. M., & Alsabeelah, N. F. (2024). Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. Biomedicine and Pharmacotherapy, 176, Article 116836. https://doi.org/10.1016/j.biopha.2024.116836

Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation. The underlying molecular mechanisms involve oxidative stress, inflammation, and neuro... Read More about Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway..

Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering (2024)
Journal Article
Vikranth, T., Dale, T., & Forsyth, N. R. (2024). Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering. Journal of Tissue Engineering and Regenerative Medicine, 2024, https://doi.org/10.1155/2024/9940673

Persistent air leaks caused by thoracic surgery, physical trauma, or spontaneous pneumothoraces are a cause of patient morbidity with need for extended chest tube durations and surgical interventions. Current treatment measures involve mechanical clo... Read More about Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering.

Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers (2024)
Journal Article
Diaz, F., Zimmermann, L., Dale, T. P., Forsyth, N. R., & Boccaccini, A. R. (2024). Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers. Carbohydrate Polymer Technologies and Applications, 7, Article 100447. https://doi.org/10.1016/j.carpta.2024.100447

Rotator cuff injuries affect a large percentage of the population worldwide. Surgical repair has rates of failure of up to 70%, and existing materials used in the reinforcement of injuries often lack appropriate mechanical properties and biodegradabi... Read More about Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers.

TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity (2024)
Journal Article
Dogan, F., & Forsyth, N. R. (in press). TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity. Biomolecules, 14(1), Article 131. https://doi.org/10.3390/biom14010131

Telomere repeats protect linear chromosomes from degradation, and telomerase has a prominent role in their maintenance. Telomerase has telomere-independent effects on cell proliferation, DNA replication, differentiation, and tumorigenesis. TERT (telo... Read More about TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity.

A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION (2024)
Presentation / Conference Contribution
Clerici, M., Ciardulli, M., Forsyth, N., Maffulli, N., & Della Porta, G. (2023, September). A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION. Presented at The European Orthopaedic Research Society (EORS) 31st Annual Meeting, Porto, Portugal

Tendon injuries are a common problem that can significantly impact an individual's quality of life. While traditional surgical methods have been used to address this issue, Extracellular Vesicles (EVs) have emerged as a promising approach to promote... Read More about A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION.