Outputs (47)

Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes (2020)
Journal Article
Chen, L., Wang, C., Forsyth, N. R., & Wu, P. (2020). Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Research and Therapy, 11, Article 319. https://doi.org/10.1186/s13287-020-01828-y

Background Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that extraembryonic stem cells in the placenta may also be affected during pregnancy. Neonatal tissue-d... Read More about Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes.

Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection (2020)
Journal Article
Dale, T., & Forsyth, N. (2020). Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection. EMBO Molecular Medicine, https://doi.org/10.15252/emmm.201810233

Severe pulmonary infection is a major threat to human health accompanied by substantial, which increases medical costs, prolonged inpatient requirements, and high mortality rates. New anti-microbial therapeutic strategies are urgently required to add... Read More about Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection.

Rock Inhibitor Y-27632 Enables Feeder-Free, Unlimited Expansion of Sus scrofa domesticus Swine Airway Stem Cells to Facilitate Respiratory Research (2019)
Journal Article
Dale, T. P., Borg D’anastasi, E., Haris, M., & Forsyth, N. R. (2019). Rock Inhibitor Y-27632 Enables Feeder-Free, Unlimited Expansion of Sus scrofa domesticus Swine Airway Stem Cells to Facilitate Respiratory Research. Stem Cells International, 2019, 1 - 15. https://doi.org/10.1155/2019/3010656

Current limitations in the efficacy of treatments for chronic respiratory disorders position them as prospective regenerative medicine therapeutic targets. A substantial barrier to these ambitions is that research requires large numbers of cells whos... Read More about Rock Inhibitor Y-27632 Enables Feeder-Free, Unlimited Expansion of Sus scrofa domesticus Swine Airway Stem Cells to Facilitate Respiratory Research.

Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities (2019)
Journal Article
Chen, L., Forsyth, N. R., & Wu, P. (2020). Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities. Journal of Tissue Engineering and Regenerative Medicine, 14(2), 243-256. https://doi.org/10.1002/term.2988

Women with gestational diabetes mellitus (GDM), and their offspring, are at high risk of developing type 2 diabetes. Chorionic (CMSCs) and amniotic mesenchymal stem cells (AMSCs) derived from placental membranes provide a source of autologous stem ce... Read More about Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities.

Hypoxia-modified cancer cell metabolism (2019)
Journal Article
Al Tameemi, W., Dale, T. P., Kh Al-Jumaily, R. M., & Forsyth, N. R. (2019). Hypoxia-modified cancer cell metabolism. Frontiers in Cell and Developmental Biology, 7(4), https://doi.org/10.3389/fcell.2019.00004

While oxygen is critical to the continued existence of complex organisms, extreme levels of oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive levels of oxygen), potentially promote stress within a defined biolog... Read More about Hypoxia-modified cancer cell metabolism.

Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types. (2018)
Journal Article
Dale, T. P., & Forsyth, N. R. (in press). Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types. BioResearch Open Access, 7(1), 10 - 24. https://doi.org/10.1089/biores.2018.0008

The poor healing capacity of cartilage and lack of effective treatment for associated disease and trauma makes it a strong candidate for a regenerative medicine approach. Potential therapies tested to date, although effective, have met with a number... Read More about Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types..

Tenogenic differentiation of human embryonic stem cells (2018)
Journal Article
Dale, T. P., Mazher, S., Webb, W. R., Zhou, J., Maffulli, N., Chen, G., …Forsyth, N. R. (2018). Tenogenic differentiation of human embryonic stem cells. Tissue engineering. Part A, 24(5-6), 361-368. https://doi.org/10.1089/ten.TEA.2017.0017

Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies. We sought to determine whether human embryonic stem cells (hE... Read More about Tenogenic differentiation of human embryonic stem cells.

P31 Role of sesquiterpene lactones against human ovarian cancer (2017)
Journal Article
Fadayomi, I. E., Forsyth, N., & Li, W. (2017). P31 Role of sesquiterpene lactones against human ovarian cancer. Biochemical Pharmacology, 139(11), 134-135. https://doi.org/10.1016/j.bcp.2017.06.032

Background: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about P31 Role of sesquiterpene lactones against human ovarian cancer.

Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles (2016)
Journal Article
Agrawal, R., Dale, T. P., Al-Zubaidi, M. A., Benny Malgulwar, P., Forsyth, N. R., & Kulshreshtha, R. (in press). Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles. PloS one, 11(10), e0164976. https://doi.org/10.1371/journal.pone.0164976

MicroRNAs are reported to have a crucial role in the regulation of self-renewal and differentiation of stem cells. Hypoxia has been identified as a key biophysical element of the stem cell culture milieu however, the link between hypoxia and miRNA ex... Read More about Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles.

Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells (2016)
Presentation / Conference
Al Azzawi, B., Merkhan, M. M., Kelly, C., & Forsyth, N. (2016, March). Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells. Poster presented at Abstracts of the Diabetes UK Professional Conference 2016, Scottish Exhibition and Conference Centre, Glasgow, Scotland

Aims:Cytokine-driven beta cell apoptosis is central to Type 1diabetes. Mesenchymal stem cells (MSCs) are multipotent cellswith significant immunomodulatory capacity, which counteractautoimmunityand enhance islet engraftment and survival. The aimof th... Read More about Mesenchymal stem cell derived products attenuate cytokine-induced apoptosis in pancreatic beta cells.