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Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis (2017)
Journal Article
Kay, A., Long, G., Broadfoot, S., Piccinini, A., Middleton, J., Kehoe, O., …Stefan, A. (2017). Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis. Scientific reports, https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis.

An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium (2017)
Journal Article
Rump, L., Mattey, D. L., Kehoe, O., & Middleton, J. (2017). An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, 97, 133-140. https://doi.org/10.1016/j.cyto.2017.05.023

Rheumatoid arthritis (RA) is a destructive and chronic autoimmune inflammatory disease. Synovial inflammation is a major feature of RA and is associated with leukocyte recruitment. Leukocytes cross the endothelial cells (ECs) into the synovial tissue... Read More about An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.

An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. (2017)
Journal Article
Rump, L., Mattey, D. L., Kehoe, O., & Middleton, J. (2017). An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, 133 - 140. https://doi.org/10.1016/j.cyto.2017.05.023

Rheumatoid arthritis (RA) is a destructive and chronic autoimmune inflammatory disease. Synovial inflammation is a major feature of RA and is associated with leukocyte recruitment. Leukocytes cross the endothelial cells (ECs) into the synovial tissue... Read More about An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium..

Novel Identification of LYVE-1 Positive Macrophages in Rheumatoid Synovial Tissue (2016)
Journal Article
Kehoe, O., Rump, L., Mattey, D., & Middleton, J. (2016). Novel Identification of LYVE-1 Positive Macrophages in Rheumatoid Synovial Tissue. Open Journal of Rheumatology and Autoimmune Diseases, 74 - 78. https://doi.org/10.4236/ojra.2016.63012

Objective: LYVE-1+ macrophages are observed in a range of cancers, where they play a role in tumour lymphangiogenesis. In rheumatoid arthritis (RA), lymphangiogenesis increases in the early stage of the disease and decreases as it progresses, potenti... Read More about Novel Identification of LYVE-1 Positive Macrophages in Rheumatoid Synovial Tissue.

Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice (2014)
Journal Article
Kehoe, O., Kalia, N., King, S., Eustace, A., Middleton, J., Boyes, C., …Patterson, A. (2014). Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice. Arthritis Research and Therapy, R148 -?. https://doi.org/10.1186/ar4610

INTRODUCTION: Syndecans are heparan sulphate proteoglycans expressed by endothelial cells. Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a role in leukocyte trafficki... Read More about Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice.

Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis (2014)
Journal Article
Kehoe, O., Cartwright, A., Askari, A., El Haj, A., & Middleton, J. (2014). Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis. Journal of Translational Medicine, 157 - ?. https://doi.org/10.1186/1479-5876-12-157

BACKGROUND: Rheumatoid arthritis (RA) is a debilitating and painful disease leading to increased morbidity and mortality and novel therapeutic approaches are needed. The purpose of this study was to elucidate if mesenchymal stem cells (MSCs) injected... Read More about Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis.

Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model (2013)
Journal Article
El Haj, A., Kehoe, O., Morris, R., & Markides, H. (2013). Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model. Stem Cell Research and Therapy, 126 -?. https://doi.org/10.1186/scrt337

INTRODUCTION: The application of mesenchymal stem cells (MSCs) in treating rheumatoid arthritis (RA) has been made possible by the immunosuppressive and differentiation abilities of these cells. A non-invasive means of assessing cell integration and... Read More about Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model.