Outputs (2)

Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A. H., Aziz, A., Alansari, R., Ferry, N., Krstic-Demonacos, M., & Ragazzon, P. (2020). Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors (2020)
Journal Article
Barnes, N. G., Parker, A. W., Ahmed Mal Ullah, A. A., Ragazzon, P. A., & Hadfield, J. A. (2020). A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors. Bioorganic and Medicinal Chemistry, 28(19), Article 115684. https://doi.org/10.1016/j.bmc.2020.115684

A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiprolife... Read More about A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.