Outputs (13)

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016)
Journal Article
Horrocks. (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLOS pathogens a peer-reviewed open-access journal published by the Public Library of Science, https://doi.org/10.1371/journal.ppat.1005763

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg... Read More about Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development (2015)
Journal Article
Horrocks. (2015). Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development. Parasites and Vectors, 81. https://doi.org/10.1186/s13071-015-0701-0

Background
Over 2700 genes are subject to stage-specific regulation during the intraerythrocytic development of the human malaria parasite Plasmodium falciparum. Bioinformatic analyses have identified a large number of over-represented motifs in the... Read More about Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development.

An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum (2012)
Journal Article
Horrocks. (2012). An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum. Malaria Journal, 42 -?. https://doi.org/10.1186/1475-2875-11-42

This report describes the optimization and evaluation of a simple single-step lysis protocol to measure luciferase bioluminescence from genetically modified Plasmodium falciparum. This protocol utilizes a modified commercial buffer to improve speed o... Read More about An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum.