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Outputs (4)

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons (2020)
Journal Article
Singh, A., Chow, O., Jenkins, S., Zhu, L., Rose, E., Astbury, K., & Chen, R. (2021). characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons. Neuroscience, 453, Article 17-31. https://doi.org/10.1016/j.neuroscience.2020.11.008

Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypo... Read More about characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons.

Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. (2020)
Journal Article
Chen, R., Hassan, H., Rawlinson, C., & Morgan, D. (2020). Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. Journal of Experimental Stroke and Translational Medicine, 13(2), 1-12

Rutin, a flavonoid with a wide range of biological activities, has a long history of use in nutritional supplements owing to its action against oxidative stress, inflammation, and hyperglycemia. Because of its pharmacological properties such as antio... Read More about Pharmacological properties of rutin and its potential uses for Alzheimer’s disease..

Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. (2020)
Journal Article
Rawlinson, C., Jenkins, S., Thei, L., Dallas, M., & Chen, R. (2020). Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain Sciences, 10(3), https://doi.org/10.3390/brainsci10030159

Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. Microglia become "activated", proliferating, and undergoing changes in morphology, gene and prot... Read More about Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy..

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020)
Journal Article
Chen. (2020). Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. Scientific reports, https://doi.org/10.1038/s41598-020-58482-w

This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apo... Read More about Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.