Outputs (3)

Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues (2020)
Journal Article
Wang, J., Roberts, S., Kuiper, J., Zhang, W., Garcia, J., Cui, Z., & Wright, K. (2020). Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues. Scientific reports, 10, Article 21658. https://doi.org/10.1038/s41598-020-78757-6

Meniscus degeneration is closely related to the progression of knee osteoarthritis (OA). However, there is currently a lack of quantitative and objective metrics to assess OA meniscal cell phenotypes. In this study we investigated the phenotypic mark... Read More about Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues.

The Use of Technology in the Subcategorisation of Osteoarthritis: a Delphi Study Approach (2020)
Journal Article
Mennan, C., Hopkins, T., Channon, A., Elliott, M., Johnstone, B., Kadir, T., …Roberts, S. (2020). The Use of Technology in the Subcategorisation of Osteoarthritis: a Delphi Study Approach. Osteoarthritis and Cartilage, 2(3), Article 100081. https://doi.org/10.1016/j.ocarto.2020.100081

Objective This UK-wide OATech+ Network consensus study utilised a Delphi approach to discern levels of awareness across an expert panel regarding the role of existing and novel technologies in osteoarthritis research. To direct future cross-disciplin... Read More about The Use of Technology in the Subcategorisation of Osteoarthritis: a Delphi Study Approach.

Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis (2020)
Journal Article
Perry, J., McCarthy, H., Bou-Gharios, G., van't Hof, R., Milner, P., Mennan, C., & Roberts, S. (2020). Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis. Osteoarthritis and Cartilage Open, 2(2), 100044 - 100044. https://doi.org/10.1016/j.ocarto.2020.100044

Objective This study investigated the effect of hUC-MSCs on osteoarthritis (OA) progression in a xenogeneic model. Design Male, 10 week-old C57Bl/6 mice underwent sham surgery (n=15) or partial medial meniscectomy (PMM;n=76). 5x105 hUC-MSCs (from 3 d... Read More about Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis.