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Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines (2017)
Presentation / Conference
Rosa Johnson-Ajinwo, O., Richardson, A., & Li, W. (2017, September). Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines. Presented at IUPHAR, Aberdeen

Ovarian cancer is the second leading cause of death among women in the gynaecological category of cancers. The current post surgery treatment which involves the use of platinum-based therapy with its attendant adverse drug-resistance often results in... Read More about Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines.

Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy (2017)
Journal Article
Weli, H. K., Akhtar, R., Chang, Z., Li, W., Cooper, J., & Yang, Y. (2017). Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy. European Journal of Obstetrics and Gynecology and Reproductive Biology, 78-85. https://doi.org/10.1016/j.ejogrb.2017.04.037

Objectives Non-enzymatic glycation is closely associated with altered mechanical properties of connective tissue. Pregnancy, marked with high levels of female hormones, confers unique alteration to the mechanical properties of pelvic connective tiss... Read More about Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy.

Antibacterial and antibiotic potentiating activities of tropical marine sponge extracts (2017)
Journal Article
Beesoo, R., Bhagooli, R., Neergheen-Bhujun, V. S., Li, W., Kagansky, A., & Bahorun, T. (2017). Antibacterial and antibiotic potentiating activities of tropical marine sponge extracts. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 81-90. https://doi.org/10.1016/j.cbpc.2017.04.001

Increasing prevalence of antibiotic resistance has led research to focus on discovering new antimicrobial agents derived from the marine biome. Although ample studies have investigated sponges for their bioactive metabolites with promising prospects... Read More about Antibacterial and antibiotic potentiating activities of tropical marine sponge extracts.

A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms (2017)
Journal Article
Aldulaimi, O., Uche a, F. I., Hameed, H., Mbye, H., Ullah, I., Drijfhout, F., …Li, W. (2017). A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms. Journal of Ethnopharmacology, 198, 221-225. https://doi.org/10.1016/j.jep.2017.01.014

Ethnopharmacological relevance and aim A decoction of the bark of Cylicodiscus gabunensis Harms is used as a traditional medicine in the treatment of malaria in Nigeria. This study aims to validate the antimalarial potency of this decoction in vitro... Read More about A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Uche, F. I., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. W. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Planta Medica, 82(S01), https://doi.org/10.1055/s-0036-1596584

Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp (2016)
Journal Article
Aldulaimi, O., & Li, W. (2016). Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp. Planta Medica, s1-s381. https://doi.org/10.1055/s-0036-1596585

Flower buds of Magnolia biondii Pamp (family Magnoliaceae) is known as Xin-Yi in the Chinese Pharmacopoeia, and is widely used for the treatment of allergic rhinitis, rhinosinusitis, nasal congestion, and headache.1 Bacterial infection caused by Stap... Read More about Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp.

Advances of Plant-Derived Natural Products in Ovarian Cancer Therapy (2016)
Journal Article
Li, W., Rosa Johnson-Ajinwo, O., & Ijeoma Uche, F. (2016). Advances of Plant-Derived Natural Products in Ovarian Cancer Therapy. International Journal of Cancer Research and Prevention, 81 - 105

Ovarian cancer is the leading cause of death in the gynaecologic cancers within the UK and US. Presently the standard treatment for ovarian cancer entails the use of chemotherapy drugs paclitaxel and carboplatin after aggressive surgical reduction in... Read More about Advances of Plant-Derived Natural Products in Ovarian Cancer Therapy.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Li, W., & Richardson, A. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata (2016)
Journal Article
Uche, F., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. (2016). Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata.