Outputs (160)

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90) (2019)
Journal Article
Reynisson. (2019). Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90). International Journal of Molecular Sciences, https://doi.org/10.3390/ijms20215333

The molecular chaperone heat shock protein 90 (Hsp90) is a current inhibition target for the treatment of diseases, including cancer. In humans, there are two major cytosolic isoforms of Hsp90 (Hsp90a and Hsp90ß). Hsp90a is inducible and Hsp90ß is co... Read More about Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90).

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. (2019)
Journal Article
Reynisson, J. (2019). New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. Molecules, https://doi.org/10.3390/molecules24203711

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usni... Read More about New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors..

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2 (2019)
Journal Article
Reynisson. (2019). Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2. Nature communications, 4639 - ?. https://doi.org/10.1038/s41467-019-12614-7

Isocitrate lyase is important for lipid utilisation by Mycobacterium tuberculosis but its ICL2 isoform is poorly understood. Here we report that binding of the lipid metabolites acetyl-CoA or propionyl-CoA to ICL2 induces a striking structural rearra... Read More about Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.

Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis. (2019)
Journal Article
Mamas. (2019). Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis. BMJ, l5476 -?. https://doi.org/10.1136/bmj.l5476

OBJECTIVE: To assess the effects of different oral antithrombotic drugs that prevent saphenous vein graft failure in patients undergoing coronary artery bypass graft surgery. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medli... Read More about Antithrombotic treatment after coronary artery bypass graft surgery: systematic review and network meta-analysis..

Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies (2019)
Journal Article
Telling, & Everett, J. (2019). Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. Cells, https://doi.org/10.3390/cells8101231

Transition metals have essential roles in brain structure and function, and are associated with pathological processes in neurodegenerative disorders classed as proteinopathies. Synchrotron X-ray techniques, coupled with ultrahigh-resolution mass spe... Read More about Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies.

Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon. (2019)
Journal Article
(2019). Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon. Clinical Anatomy, https://doi.org/10.1002/ca.23490

INTRODUCTION: The fibrocartilagenous plantar plates of the forefoot are biomechanically important, forming the primary distal attachment for the plantar aponeurosis. They are integral to the function of the windlass mechanism in supporting the arches... Read More about Properties and Function of the Flexor Hallucis Capsularis Interphalangeus Tendon..

The effect of high glucose on lipid metabolism in the human placenta (2019)
Journal Article
Hulme. (2019). The effect of high glucose on lipid metabolism in the human placenta. Scientific reports, https://doi.org/10.1038/s41598-019-50626-x

Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose co... Read More about The effect of high glucose on lipid metabolism in the human placenta.

Prediction of pathological fracture in patients with metastatic disease of the lower limb (2019)
Journal Article
Cool. (in press). Prediction of pathological fracture in patients with metastatic disease of the lower limb. Scientific reports, 9, Article 14133. https://doi.org/10.1038/s41598-019-50636-9

The aim of this study was to investigate if the risk of pathological fracture can be predicted with the proportion of body weight that can be put through the affected leg in patients with metastatic bone disease of the lower limb. A prospective obser... Read More about Prediction of pathological fracture in patients with metastatic disease of the lower limb.

Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential (2019)
Journal Article
Mennan, C., Garcia, J., McCarthy, H., Owen, S., Perry, J., Wright, K., …Roberts, S. (2019). Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential. Cartilage, 10(4), 467-479. https://doi.org/10.1177/1947603518769714

Objective To assess the phenotype of human articular chondrocytes cultured in normoxia (21% O2) or continuous hypoxia (2% O2). Design Chondrocytes were extracted from patients undergoing total knee replacement (n = 5) and cultured in ~21% (normo... Read More about Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential.

Virtual patient educational intervention for the development of shared decision-making skills: a pilot study. (2019)
Journal Article
Jacklin, S., Chapman, S., & Maskrey, N. (2019). Virtual patient educational intervention for the development of shared decision-making skills: a pilot study. BMJ Simulation and Technology Enhanced Learning, 215 - 217

Background: Shared decision-making (SDM) involves a healthcare professional and a patient forming a congruent partnership, within which information is shared and decisions are made which align with the patient's values. SDM does not occur to the exte... Read More about Virtual patient educational intervention for the development of shared decision-making skills: a pilot study..