Outputs (160)

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. (2019)
Journal Article
Wragg. (2019). Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Molecular Neurobiology, 6156 - 6167. https://doi.org/10.1007/s12035-019-1500-y

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a... Read More about Systematic Review of miRNA as Biomarkers in Alzheimer's Disease..

Effect of journal cylindricity error with saddle or drum distribution on the performance of hydrodynamic journal bearing systems (2019)
Journal Article
Li, B., Zhou, D., Ogrodnik, P., & Xu, W. (2020). Effect of journal cylindricity error with saddle or drum distribution on the performance of hydrodynamic journal bearing systems. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 234(7), 1092-1105. https://doi.org/10.1177/1350650119876221

The present study investigates the effect of cylindricity error on the performance of hydrodynamic journal bearing systems. Two types of cylindricity errors of the journal, namely the drum shape distribution cylindricity error (DCE) and the saddle sh... Read More about Effect of journal cylindricity error with saddle or drum distribution on the performance of hydrodynamic journal bearing systems.

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA. The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity. More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

Social Media: The New Paradigm for Cardiovascular Case Reports (2019)
Journal Article
Mamas, M. (2019). Social Media: The New Paradigm for Cardiovascular Case Reports. https://doi.org/10.1016/j.jaccas.2019.08.002

Viewpoint article.

Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes. (2019)
Journal Article
Heald, A., Davies, M., Stedman, M., Livingston, M., Lunt, M., Fryer, A., & Gadsby, R. (2019). Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes. BMJ Open, 9(9), e028278 - ?. https://doi.org/10.1136/bmjopen-2018-028278

OBJECTIVE: Evaluate relative clinical effectiveness of treatment options for type 2 diabetes mellitus (T2DM) using a statistical model of real-world evidence within UK general practitioner practices (GPP), to quantify the opportunities for diabetes c... Read More about Analysis of English general practice level data linking medication levels, service activity and demography to levels of glycaemic control being achieved in type 2 diabetes to improve clinical practice and patient outcomes..

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial (2019)
Journal Article
(2019). Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. The Lancet, https://doi.org/10.1016/S0140-6736%2819%2932039-2

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronar... Read More about Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter? (2019)
Journal Article
Mamas. (2019). Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?. European Journal of Preventive Cardiology, 2047487319871709 - 2047487319871709. https://doi.org/10.1177/2047487319871709

Background Whilst antithrombotic therapy is recommended in people with atrial fibrillation, little is known about the survival benefits of antithrombotic treatment in those with both high ischaemic and bleeding risk scores. We aim to describe the dis... Read More about Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?.

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle (2019)
Journal Article
Holt, I., Fuller, H., Lam, L., Sewry, C., Shirran, S., Zhang, Q., …Morris, G. (2019). Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle. Scientific reports, https://doi.org/10.1038/s41598-019-50728-6

Nesprins, nuclear envelope spectrin-repeat proteins encoded by the SYNE1 and SYNE2 genes, are involved in localization of nuclei. The short isoform, nesprin-1-alpha2, is required for relocation of the microtubule organizer function from centromeres t... Read More about Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes (2019)
Journal Article
(2019). Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes. Advances in therapy, 2547 - 2557. https://doi.org/10.1007/s12325-019-01066-6

Inhalable medications for patients with asthma and chronic obstructive pulmonary disease (COPD) can be confusing even for health care professionals because of the multitude of available devices each with different operating principles. Dry powder inh... Read More about Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes.

Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry (2019)
Journal Article
Roffe. (2019). Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry. Diabetes, db190440 - db190440. https://doi.org/10.2337/db19-0440

Available data from observational studies on the association of admission hyperglycaemia (aHG) with outcomes of acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) are contradictory especially when stratified by diabetes... Read More about Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry.