Outputs (117)

Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. (2021)
Journal Article
(2021). Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. Cells, https://doi.org/10.3390/cells10112819

BACKGROUND: Liver transplantation remains the only viable therapy for liver failure but has a severely restricted utility. Here, we aimed to decellularize rat livers to form acellular 3D bio-scaffolds suitable for seeding with induced pluripotent cel... Read More about Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation..

Fragility Fractures: Risk Factors and Management in the Elderly. (2021)
Journal Article
(2021). Fragility Fractures: Risk Factors and Management in the Elderly. https://doi.org/10.3390/medicina57101119

Given the progressive ageing of Western populations, the fragility fractures market has a growing socioeconomic impact. Fragility fractures are common in the elderly, negatively impacting their quality of life, limiting autonomy, increasing disabilit... Read More about Fragility Fractures: Risk Factors and Management in the Elderly..

Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury (2021)
Journal Article
Chen. (2021). Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury. Spinal Cord, 1216 - 1218. https://doi.org/10.1038/s41393-021-00711-8

AbstractDegenerative cervical myelopathy (DCM) is a common non-traumatic spinal cord disorder and characterized by progressive neurological impairment. Generally, it is still underdiagnosed and referral to spine specialists is often late, when patien... Read More about Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury.

Outpatient Total Knee Arthroplasty: A Meta-Analysis (2021)
Journal Article
(2021). Outpatient Total Knee Arthroplasty: A Meta-Analysis. Applied Sciences, 9376 - 9376. https://doi.org/10.3390/app11209376

Introduction: Outpatient total knee arthroplasty (TKA) is attracting growing interest. This meta-analysis compared patient reported outcome measures (PROMs), infection, readmission, revision, deep vein thrombosis (DVT), and mortality rates of outpati... Read More about Outpatient Total Knee Arthroplasty: A Meta-Analysis.

Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases (2021)
Journal Article
Paraskevaidi, M., Baker, M., Butler, H., Byrne, H., Chakkumpulakkal, T., Loren, C., …Wood, B. (2021). Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases. Applied Spectroscopy Reviews, https://doi.org/10.1080/05704928.2021.1946076

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the... Read More about Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases.

Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature (2021)
Journal Article
Migliorini, F., La Padula, G., Torsiello, E., Spiezia, F., Oliva, F., & Maffulli, N. (2021). Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature. European Journal of Medical Research, 26(1), Article ARTN 118. https://doi.org/10.1186/s40001-021-00593-9

Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and provide the best functional outcomes. Allograft, vascularized fibular or i... Read More about Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature.

Investigation of the blood proteome in response to spinal cord injury in rodent models (2021)
Journal Article
Hulme, C. H., Fuller, H. R., Riddell, J., Shirran, S. L., Botting, C. H., Osman, A., & Wright, K. T. (2022). Investigation of the blood proteome in response to spinal cord injury in rodent models. Spinal Cord, 60(4), 320-325. https://doi.org/10.1038/s41393-021-00692-8

STUDY DESIGN: Explanatory and Mechanistic Study OBJECTIVES: A better understanding of the ‘whole-body’ response following spinal cord injury (SCI) is needed to guide future research aimed at developing novel therapeutic interventions and identifying... Read More about Investigation of the blood proteome in response to spinal cord injury in rodent models.

Dystrophin involvement in peripheral circadian SRF signalling (2021)
Journal Article
Bowerman. (2021). Dystrophin involvement in peripheral circadian SRF signalling. https://doi.org/10.26508/lsa.202101014

Absence of dystrophin, an essential sarcolemmal protein required for muscle contraction, leads to the devastating muscle-wasting disease Duchenne muscular dystrophy. Dystrophin has an actin-binding domain, which binds and stabilises filamentous-(F)-a... Read More about Dystrophin involvement in peripheral circadian SRF signalling.

Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells (2021)
Journal Article
Fadayomi, I. E., Johnson-Ajinwo, O. R., Pires, E., McCullagh, J., Claridge, T. D., Forsyth, N. R., & Li, W. (2021). Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells. Molecules, 26(19), 5933 - 5933. https://doi.org/10.3390/molecules26195933

Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a promising approach towards finding safer anticancer therapeutics. Justicia insularis T. Anderson... Read More about Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.

Slowed-Down Rehabilitation Following Percutaneous Repair of Achilles Tendon Rupture. (2021)
Journal Article
(2021). Slowed-Down Rehabilitation Following Percutaneous Repair of Achilles Tendon Rupture. Foot and Ankle International, 10711007211038594 - ?. https://doi.org/10.1177/10711007211038594

BACKGROUND: Following percutaneous repair of acute Achilles tendon (AT) ruptures, early postoperative weightbearing is advocated; however, it is debatable how aggressive rehabilitation should be. We compared the clinical and functional outcomes in 2... Read More about Slowed-Down Rehabilitation Following Percutaneous Repair of Achilles Tendon Rupture..