Outputs (127)

Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions (2021)
Journal Article
Barnes, N. G., Ahmed Mal Ullah, A. A., Ragazzon, P. A., Charafi, N., & Hadfield, J. A. (2021). Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions. ChemistrySelect, 6(28), 7082 - 7086. https://doi.org/10.1002/slct.202101960

Combretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. (2021)
Journal Article
(2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model..

Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019) (2021)
Journal Article
Goenaga Infante, H., Warren, J., Chalmers, J., Dent, G., Todoli, J. L., Collingwood, J., Telling, N., Resano, M., Limbeck, A., Schoenberger, T., Hibbert, D. B., LeGresley, A., Adams, K., & Craston, D. (2021). Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019). Pure and Applied Chemistry, 93(6), 647 - 776. https://doi.org/10.1515/pac-2019-0203

Recommendations are given concerning the terminology of concepts and methods used in spectroscopy in analytical chemistry, covering nuclear magnetic resonance spectroscopy, atomic spectroscopy, and vibrational spectroscopy.

Development of 2-Morpholino-N-hydroxybenzamides as anti-proliferative PC-PLC inhibitors (2021)
Journal Article
Rees, S. W., Leung, E., Reynisson, J., Barker, D., & Pilkington, L. I. (2021). Development of 2-Morpholino-N-hydroxybenzamides as anti-proliferative PC-PLC inhibitors. Bioorganic Chemistry, 114, 105152. https://doi.org/10.1016/j.bioorg.2021.105152

Phosphatidylcholine-specific phospholipase C (PC-PLC) is a key enzyme involved in the metabolism of the mammalian phospholipid phosphatidylcholine into secondary messengers diacylglycerol (DAG) and phosphocholine. DAG and phosphocholine have been ide... Read More about Development of 2-Morpholino-N-hydroxybenzamides as anti-proliferative PC-PLC inhibitors.

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. (2021)
Journal Article
Reynisson. (2021). New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. Biomolecules, https://doi.org/10.3390/biom11070973

Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-... Read More about New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition..

Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis (2021)
Journal Article
(2021). Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Crohn's & Colitis 360, https://doi.org/10.1093/crocol/otab041

<jats:title>Abstract</jats:title> <jats:p>Abdominal pain is a key symptom of inflammatory bowel disease (IBD), particularly in active IBD, but also occurs in patients with quiescent disease suggesting that mechanisms other than active inflammation ma... Read More about Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. (2021)
Journal Article
Reynisson, J. (2021). Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncology and Therapy,

Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as ch... Read More about Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs..

Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells. (2021)
Journal Article
Reynisson. (2021). Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells. Medicines, https://doi.org/10.3390/medicines8070032

The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It is mediated by E-selectin and its ligands, of which the most s... Read More about Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells..

Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician. (2021)
Journal Article
(2021). Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician. Journal of Orthopaedic Surgery and Research, https://doi.org/10.1186/s13018-021-02524-0

BACKGROUND: Hip fractures are common in elderly patients, in whom it is important to monitor blood loss; however, unnecessary transfusions should be avoided. The primary objective of this study was to assess whether the employment of a dedicated orth... Read More about Haemoglobin and transfusions in elderly patients with hip fractures: the effect of a dedicated orthogeriatrician..

Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students (2021)
Journal Article
White, S., Gifford, A., & Frisher, M. (2021). Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students. Pharmacy Education, 21(1), 56 - 64. https://doi.org/10.46542/pe.2021.211.5664

Description: Students in small groups designed, delivered and evaluated real-life health promotion campaigns in the local community. A peer assessed component was included from the fifth cohort onwards. Evaluation: Six successive cohorts of pharmacy... Read More about Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students.