Outputs (10)

Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells (2021)
Thesis
Fadayomi, I. E. (2021). Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells. (Thesis). Keele University

Ovarian cancer is a gynaecological malignancy associated with the highest level of death. Its resistance against anti-cancer drugs in recent time has exacerbated the problem. Hence, the search for novel drugs from plants used in traditional medicine... Read More about Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells.

Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study (2021)
Thesis
Chatzixenitidis, A. (2021). Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study. (Thesis). Keele University

Background and aim: Information support is an integral part of cancer care, but its provision can be problematic in busy health settings. The aim of this project was to develop and evaluate a health app to facilitate the provision of information supp... Read More about Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study.

Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs (2021)
Thesis
Alansari, R. H. A. (2021). Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs. (Thesis). Keele University

The human body hosts a vast number of microorganisms such as bacteria, archaea, and viruses that are colonised inside and outside the body. This combination of microorganisms living within the human body is known as microbiota. The human microbiota v... Read More about Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs.

Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications (2021)
Thesis
Wang, J. (2021). Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications. (Thesis). Keele University

As a vital part of the knee joint, the meniscus acts to prevent the degeneration of articular cartilage and the onset of knee osteoarthritis (OA). Repairing meniscus injuries in the avascular region is still a challenge in orthopaedics. The current p... Read More about Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications.

Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19 (2021)
Thesis
Faux-Nightingale, A. H. (2021). Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19. (Thesis). Keele University

This project assesses the benefit that qualitative investigation of experience brings to healthcare research. It does this through: Phase One - Understanding the factors affecting AFO compliance in children with CP People with cerebral palsy (CP)... Read More about Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19.

The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins (2021)
Thesis
Njoroge, W. (2021). The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins. (Thesis). Keele University

Cardiovascular disease (CVD) has been identified as the leading cause of mortality in westernised society. The triggering factor for the majority of cardiovascular diseases is atherosclerosis, defined as an accumulation of fatty materials in the vasc... Read More about The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins.

A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors (2021)
Thesis
Odingo, M. O. (2021). A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors. (Thesis). Keele University

Introduction A new class of lipid lowering agent Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors (PCSK9) was launched in 2015 for the treatment of heterozygous familial hypercholesterolemia (HeFH) in combination with statin therapy. There a... Read More about A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors.

Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes (2021)
Thesis
Bhunia, S. (2021). Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes. (Thesis). Keele University

The fetal membrane surrounds and supports the developing fetus during the pregnancy. The cellular structure of the fetal membrane and the proteins synthesized by the cells of amniotic and chorionic membranes, maintain the mechanical integrity of the... Read More about Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes.

Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models (2021)
Thesis
Green, E. L. (2021). Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models. (Thesis). Keele University

Parkinson’s disease (PD) is characterised by motor symptoms caused by degeneration of dopaminergic neurons in the substantia nigra. The cause remains elusive and current treatments cannot halt or reverse progression. This thesis explores the effects... Read More about Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models.

Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee (2021)
Thesis
Hopkins, T. (2021). Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee. (Thesis). Keele University

Damage to the articular cartilage (AC) in the human knee, caused by physical trauma or degenerative disease, represents a common and complex clinical problem. AC has a very limited capacity for self-repair and, once damaged, rarely heals spontaneousl... Read More about Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee.