Outputs (177)

Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation
Thesis
Baba Ismail, Y. M. (2016). Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation

The most common clinical treatments for large bone deficiencies resulting from trauma, disease or infection are autograft, allograft or bone graft substitutes (BGS). However, these treatments still have limitations for clinical applications. Thus, th... Read More about Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation.

Novel tissue engineering approaches to enhance natural bone formation
Thesis
Deegan, A. J. (2016). Novel tissue engineering approaches to enhance natural bone formation

The bone tissue engineering community has been striving to develop novel approaches that mimic natural bone formation. The rapid generation of mineralised bone tissue with a capacity for vascularisation and the selection of highly osteogenic cell sou... Read More about Novel tissue engineering approaches to enhance natural bone formation.

Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer
Thesis
(2016). Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer

Autotaxin is an extracellular phospholipase D that catalyses the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer.

Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer
Thesis
Malekigorji, M. (2016). Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most common epithelial, exocrine pancreatic malignancy. Gemcitabine, as the only chemotherapy clinically available for pancreatic cancer, proves effective only in 23.8% of patients. Recently, iron oxide-... Read More about Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer.

Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering
Thesis
Rotherham, M. (2016). Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering

The Wnt signalling pathways play crucial roles in development, tissue patterning, and stem cell fate determination. These pathways are therefore an attractive therapeutic target in the field of regenerative medicine and tissue engineering. Magnetic n... Read More about Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering.

Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes
Thesis
metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes

Introduction: Pneumonia contributes significantly to the morbidity and mortality in stroke patients, especially those fed via nasogastric tubes. Methods: This project was conducted in two steps; 1. A randomised controlled trial: The efficacy of p... Read More about Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes.

An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint
Thesis
Garcia, J. K. (2017). An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint

Osteoarthritis (OA) is a debilitating joint disease characterised by pain and progressive destruction of elements such as articular cartilage. Autologous chondrocyte implantation is a cellular therapy developed to regenerate damaged cartilage and del... Read More about An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint.

Diels Alder-mediated release of gemcitabine from nanoparticles: developing improved methods for pancreatic cancer drug delivery
Thesis
(2017). Diels Alder-mediated release of gemcitabine from nanoparticles: developing improved methods for pancreatic cancer drug delivery

Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC), is the deadliest type of cancerous malignancy with a survival rate of only 3.7 % after 5 years. The first line current treatment is a drug called gemcitabine, which has been shown to displ... Read More about Diels Alder-mediated release of gemcitabine from nanoparticles: developing improved methods for pancreatic cancer drug delivery.

The combination of polyhydroxyalkanoates, collagen and stem cells for application in tendon tissue engineering
Thesis
(2013). The combination of polyhydroxyalkanoates, collagen and stem cells for application in tendon tissue engineering

Polyhydroxyalkanoates (PHA) are biopolymer molecules that have shown increasing evidence of suitability for use as biomaterials. Many different cell types from a range of species have been shown to adhere and develop on PHA scaffolds, with some prel... Read More about The combination of polyhydroxyalkanoates, collagen and stem cells for application in tendon tissue engineering.

Volatile biomarkers emitted by cell cultures: headspace analysis using selected ion flow tube mass spectrometry, SIFT-MS
Thesis
(2013). Volatile biomarkers emitted by cell cultures: headspace analysis using selected ion flow tube mass spectrometry, SIFT-MS

The work presented in this thesis was initiated in order to develop a non-invasive real-time gas phase analytical technique, based on selected ion flow tube mass spectrometry (SIFT-MS), for monitoring the progression of human cell cultures and the de... Read More about Volatile biomarkers emitted by cell cultures: headspace analysis using selected ion flow tube mass spectrometry, SIFT-MS.