Outputs (177)

Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology
Thesis
(2018). Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology

Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tis... Read More about Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology.

Pro-drug strategies for pancreatic cancer therapy
Thesis
(2018). Pro-drug strategies for pancreatic cancer therapy

Pancreatic cancer is the fourth main cancer in the western world. Currently the only chemotherapy available clinically is gemcitabine. However, gemcitabine treatment only proves effective in 23.8% of patients. Nano-structures (

Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology
Thesis
(2018). Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology

A novel method for monitoring of pharmaceutically relevant reactions using PADI-MS has been developed in this study. The visible non-thermal plasma plume from a coaxial helium gas flow non-thermal RF plasma was optimised using a range of samples. PAD... Read More about Towards monitoring of the progress of chemical reactions using a novel plasma-assisted desorption ionisation mass spectrometry methodology.

Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer
Thesis
(2018). Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer

Several long non-coding RNAs (lncRNAs) have been identified to play key, rate-limiting roles in malignancies, and the mechanisms involved are now being elucidated. This study addressed the roles of NEAT1 and MIAT lncRNAs, in breast cancer. The short... Read More about Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer.

Evaluation of the Mevalonate Pathway as a Target for the Treatment of Ovarian Cancer
Thesis
(2018). Evaluation of the Mevalonate Pathway as a Target for the Treatment of Ovarian Cancer

Ovarian cancer is the 5th leading cause of cancer-related death. The disease responds initially to treatment which is most often surgical cytoreduction followed by chemotherapy. The primary response rates to chemotherapy are approximately 80%. Unfort... Read More about Evaluation of the Mevalonate Pathway as a Target for the Treatment of Ovarian Cancer.

Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression
Thesis
(2018). Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression

Human mesenchymal stem cells (hMSCs) have multiple potential roles in regenerative medicine. These roles revolve around the exploitation of their multipotent differentiation potential, their immunogenic privilege, or the broad range of molecules they... Read More about Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression.

Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy
Thesis
(2018). Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy

Ovarian cancer is a complex disease characterized by low incidence, accounting for about 4% of cancer diagnoses in women, but with rapid progression and higher mortality rate than any other gynecological malignancy. Approximately 70 % of the cases ar... Read More about Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy.

The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair
Thesis
(2018). The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair

Aims To evaluate the in vitro potential of umbilical cord(UC)-derived cells as an allogeneic cell source that could be used ‘off-the-shelf’ in orthopaedics for bone and cartilage regeneration. The study also assesses the in-vivo efficacy of cell the... Read More about The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair.

Electrolytic growth processes with applications to adaptive systems
Thesis
(1963). Electrolytic growth processes with applications to adaptive systems

Two types of electrolytic growth processes have been investigated as possible means of controlling impedances in adaptive systems. One of these entails the growth of conductors by metallic deposition and the other the growth of insulation by anodic o... Read More about Electrolytic growth processes with applications to adaptive systems.

Validating models of injury risk prediction in football players
Thesis
(2018). Validating models of injury risk prediction in football players

Association football (soccer) is a popular sport and there is a high risk of injury for participants. Within the context of professional clubs, the risk of injury is also associated with the risk of financial costs. Therefore, injury reduction proces... Read More about Validating models of injury risk prediction in football players.