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Outputs (177)

The validation of the Royal Stoke Pharmacy Workforce Calculator – a mixed methods study
Thesis
(2018). The validation of the Royal Stoke Pharmacy Workforce Calculator – a mixed methods study

Background The Royal Stoke Pharmacy Workforce Calculator (RSPWC) was developed to meet a local need of identifying clinical pharmacy staffing levels, not described nationally. This study demonstrates the validity and transferability of the RSPWC an... Read More about The validation of the Royal Stoke Pharmacy Workforce Calculator – a mixed methods study.

Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes
Thesis
(2018). Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes

The islets of Langerhans are multicellular aggregates within the pancreas containing beta cells that sense changes in blood glucose level and respond by secreting insulin. The cells within the islets communicate with each other through gap junctions.... Read More about Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes.

Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery
Thesis
(2018). Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery

With the advent of powerful gene editing tools such as CRISPR/Cas9, advances in gene therapy have gained a second wind. Despite this, disease therapy still has not progressed beyond clinical trials due to limitations in current delivery methods. The... Read More about Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery.

Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis
Thesis
(2018). Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis

In this project, we have designed, constructed, and validated a human tissue-engineered blood vessel construct (TEBV) to assess whether it could be used as a new model system in which to study thrombus formation under physiologically relevant conditi... Read More about Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis.

Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse
Thesis
Kinikanwo Weli, H. (2018). Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse

Introduction: Pelvic organ prolapse is present in up to 50% of women. It is commoner in older women, often above 50 years of age and associated with hormonal e.g. oestrogen decline, and stiffer vaginal tissue. Pregnancy, on the contrary is a physiolo... Read More about Changes in advanced glycation content, structural and mechanical properties of vaginal tissue during pregnancy and in prolapse.

Pharmacists in general medical practice: a case study of clinical commissioning groups
Thesis
Saunders, R. E. (2018). Pharmacists in general medical practice: a case study of clinical commissioning groups

Pharmacists have been identified to address the increasing workload in United Kingdom (UK) general practice. A pilot has been commissioned by National Health Service England (NHSE) to upskill pharmacists for this purpose. Evaluation is underway and e... Read More about Pharmacists in general medical practice: a case study of clinical commissioning groups.

Silicon in health: A beneficial element in reducing the body burden of aluminium
Thesis
Jones, K. L. (2018). Silicon in health: A beneficial element in reducing the body burden of aluminium

The essentiality of silicon and the toxicity of aluminium within humans are both topics of much debate; the current conception is that silicon is essential in ameliorating aluminium toxicity, however, the evidence for this remains inconclusive. T... Read More about Silicon in health: A beneficial element in reducing the body burden of aluminium.

Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation
Thesis
Ali, I. F. (2018). Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation

The emergence and spread of resistance to antimalarial drugs has highlighted the demand to search for new drugs that target novel pathways in the human malaria parasite Plasmodium falciparum. This thesis explores the potential for targeting of the Pf... Read More about Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation.

Implementation and evaluation of a computerised anticoagulation decision support tool for managing atrial fibrillation
Thesis
Hijazeen, R. (2018). Implementation and evaluation of a computerised anticoagulation decision support tool for managing atrial fibrillation

Background: Anticoagulation therapy for patients with atrial fibrillation (AF) remains a national challenge. A decision support tool (DST) was developed to assist healthcare professionals (HCPs) in the appropriate prescribing of anticoagulants in pat... Read More about Implementation and evaluation of a computerised anticoagulation decision support tool for managing atrial fibrillation.