Outputs (177)

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. (2016). A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands

INTRODUCTION: Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes. AIM: To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D
Thesis
(2012). Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D

In this thesis, recognition of the complex natural ligand lipopolysaccharide (LPS) by the innate immune proteins C-reactive protein (CRP) from Limulus polyphemus (Atlantic horseshoe crab), and human surfactant protein D, in the form of a recombinant... Read More about Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D.

Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes
Thesis
(2012). Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes

Pathological conditions of cartilage resulting from acute injury are a major cause of morbidity. Surgical intervention, in most cases, does not repair cartilage to its native mechanical resilience. The potential benefits of non-invasive approaches fo... Read More about Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes.

The influence of the microenvironment on vascularisation of osteochondral tissues
Thesis
(2012). The influence of the microenvironment on vascularisation of osteochondral tissues

The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Articular cartilage is an avascular tissue and the presence of blood vessels is associated with various pathologies of the tissue. Conversely, bone requir... Read More about The influence of the microenvironment on vascularisation of osteochondral tissues.

Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis
Thesis
(2013). Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis

Aim: This thesis explores the complex cellular and biological interrelationships involved in Idiopathic Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis. Methods and results: 21 IPF and 19 control lung tissues were... Read More about Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis.

Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations
Thesis
(2013). Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations

Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide. Identifying and avoiding disease progression risk factors is important in the management of CKD. Non-Steroidal Anti-inflammatory Drugs (NSAIDs), which are commonly pr... Read More about Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations.

Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection
Thesis
(2013). Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection

Two major components of the common carp Cyprinus carpio innate response, i.e. the C-reactive protein (CRP) and the complement system, have been analysed in common carp either orally immunostimulated with ß-glucan or infected with a pathogen or both.... Read More about Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection.