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Outputs (185)

An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells
Thesis
An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells. https://keele-repository.worktribe.com/output/418482

Type 1 diabetes is a challenging condition to manage effectively. Utilising the mesenchymal stem cell (MSC) secretome is an avenue being researched in regenerative medicine which could potentially ameliorate the condition. Previous studies have ident... Read More about An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells.

Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes
Thesis
Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes. https://keele-repository.worktribe.com/output/418484

Recent study suggested that the anti-platelet effect of nicergoline is caused by inhibiting agonist-evoked Ca2+ signalling by disrupting the normal localization of the dense tubular system in human platelets. This effect is brought about by the disru... Read More about Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes.

The function of sodium/calcium ion exchanger in human platelets and megakaryocytes
Thesis
The function of sodium/calcium ion exchanger in human platelets and megakaryocytes. https://keele-repository.worktribe.com/output/418586

Previously work from our lab has predicted that Ca2+ release from intracellular Ca2+ stores occurs into a Na+/Ca2+ exchanger (NCX)-associated cytosolic nanodomain enclosed within the membrane complex. In this study, we aimed to test the hypothesis th... Read More about The function of sodium/calcium ion exchanger in human platelets and megakaryocytes.

Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer
Thesis
Sivakumar, R. Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer. https://keele-repository.worktribe.com/output/422989

Cyclin D1 is a key regulatory protein in the progression of G1-S phase of the cell cycle. Activated Cyclin D1 in turn activates S phase proteins and thereby leading to cell proliferation. Over expression of Cyclin D1 leads S phase cell cycle progress... Read More about Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer.

Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair
Thesis
Sharma, R. Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair. https://keele-repository.worktribe.com/output/423752

Background: An injury to the wrist and hand can impact different anatomical structures. Any damage or cut to the flexor tendons can leave a devastating impact if not treated well and can therefore compromise our daily physical activities. Surgery and... Read More about Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair.

Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index
Thesis
Moody, D. K. Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index. https://keele-repository.worktribe.com/output/423753

Frailty measurement in primary care and at transitions of care is needed to enable timely identification of frailty, guide interventions and support proactive, integrated care. However, there is currently no single tool for frailty measurement in the... Read More about Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index.

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. Optimising canine olfactory ensheathing cell therapy using tissue engineering tools. https://keele-repository.worktribe.com/output/423884

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands. https://keele-repository.worktribe.com/output/423887

INTRODUCTION:
Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes.

AIM:
To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D
Thesis
Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D. https://keele-repository.worktribe.com/output/423973

In this thesis, recognition of the complex natural ligand lipopolysaccharide (LPS) by the innate immune proteins C-reactive protein (CRP) from Limulus polyphemus (Atlantic horseshoe crab), and human surfactant protein D, in the form of a recombinant... Read More about Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D.