Outputs (176)

New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies (2020)
Thesis
Basit, R. H. (2020). New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies. (Thesis). Keele University

Penetrating traumatic brain injury (pTBI) causes significant neural damage and debilitation. The management of pTBI is largely supportive currently, with no clinically established regenerative therapies. Researchers have previously evaluated the rege... Read More about New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies.

Developing neural transplant cell sprays for neurological injuries (2020)
Thesis
Woods, W. A. (2020). Developing neural transplant cell sprays for neurological injuries. (Thesis). Keele University

Regeneration of the central nervous system following penetrating traumatic brain injury (pTBI) represents a significant clinical challenge. Neural cell therapies have the potential to promote regeneration in central neural injury. However, such thera... Read More about Developing neural transplant cell sprays for neurological injuries.

Translational studies to support the use of pitavastatin as a cancer therapeutic (2020)
Thesis
Jawad, M. J. (2020). Translational studies to support the use of pitavastatin as a cancer therapeutic. (Thesis). Keele University

Ovarian cancer is the fifth leading cause of death associated with cancer. Initially, the disease responds to surgical cytoreduction, followed by chemotherapy. The primary response rate for chemotherapy is about 80%. Unfortunately, most patients rela... Read More about Translational studies to support the use of pitavastatin as a cancer therapeutic.

Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways (2020)
Thesis
Šoltić, D. (2020). Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways. (Thesis). Keele University

Spinal muscular atrophy (SMA) is a debilitating genetic disorder, characterised by homozygous loss of the survival of motor neuron 1 (SMN1) gene, resulting in insufficient levels of ubiquitously expressed survival of motor neuron (SMN) protein. The t... Read More about Proteomics-based identification and characterisation of spinal muscular atrophy disease pathways.

Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents (2020)
Thesis
Abdulrahman, M. F. A. (2020). Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents. (Thesis). Keele University

The rate-limiting step for oral absorption of hydrophobic drugs and solubility is the drug dissolution rate in the GI fluids. Several novel and traditional methods have been used to improve the solubility rates of poorly water soluble drugs. The prof... Read More about Synthesis of highly functionalised calix[4]resorcinarenes and their application as drug solubilising agents.

Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum (2020)
Thesis
Famodimu, M. T. (2020). Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University

The emergence of P. falciparum resistant to current front-line artemisinin combination therapies underscores the urgent demand for new candidate molecules for a single exposure radical cure and prophylaxis drug. Developing a suitable candidate compon... Read More about Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum.

Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies (2020)
Thesis
Morgan, R. L. (2020). Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies. (Thesis). Keele University

Cells secrete small membrane-bound extracellular vesicles (sEVs) called exosomes. These vesicles contain a mixture of protein, lipids, nucleic acids and saccharides (known collectively as cargo) that mediate therapeutic effects similar to their produ... Read More about Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies.

Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo (2020)
Thesis
Turner, D. C. (2020). Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo. (Thesis). Keele University

Skeletal muscle (SkM) is an extremely abundant and mechano-sensitive tissue, demonstrating increases in mass and function following mechanical loading/resistance exercise (RE). Over the past 3 decades, there has been considerable progress in the deve... Read More about Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo.

Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis (2020)
Thesis
Kirkby, M. (2020). Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis. (Thesis). Keele University

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide that has been used extensively for the past half century as a topical antiseptic, due to its ability to effectively kill surface bacteria with minimal reports of resistance. However, bacteria... Read More about Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis.

Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer (2020)
Thesis
Ali Asgari, M. (2020). Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is the 4th most aggressive cancer in the Western world. There are very little drugs available as chemotherapies for the treatment of pancreatic cancer. Of the ones used, most of them become eliminated by first pass metabolism before... Read More about Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer.