Outputs (170)

The investigation of surface chemical and nanotopographical cues to engineer biointerfaces
Thesis

This thesis is focused on understanding the fundamental physical interaction occurring, when a material interacts with a biological fluid containing protein molecules and cells. The interaction of proteins with defined surface chemistry and nanotopog... Read More about The investigation of surface chemical and nanotopographical cues to engineer biointerfaces.

Expression and functionality of beta-chemokines in endothelial cells of the rheumatoid synovium
Thesis

RA is a destructive and chronic autoimmune inflammatory disease. The inflammation of the synovium is associated with the local invasion of inflammatory cells across blood vessel endothelial cells (ECs), increases in synovial fluid volume and local pa... Read More about Expression and functionality of beta-chemokines in endothelial cells of the rheumatoid synovium.

The role of neuromuscular electrical stimulation in reversing age-related and pathological muscle atrophy
Thesis

An ageing population increases the number of frail, elderly individuals. Physiotherapists are increasingly treating frail individuals due to the associated rate of rapid muscle atrophy. A rapid loss of muscle strength can result in difficulty perform... Read More about The role of neuromuscular electrical stimulation in reversing age-related and pathological muscle atrophy.

Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis
Thesis

Background: It is now widely accepted that physical training therapy is more reliable and effective than medication in improving fatigue in patients with Multiple Sclerosis (MS). However, efforts are still being made to maximise the benefits of train... Read More about Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis.

Directing stem cell differentiation towards a neuronal fate using nicotinamide
Thesis

Neuronal cell loss and damage in the central nervous system are characteristics of debilitating brain related-degenerative disorders such as Parkinson’s disease. The last four decades of research have focused on the promise of cell replacement therap... Read More about Directing stem cell differentiation towards a neuronal fate using nicotinamide.

Fabrication of functional basal ganglia circuitry in vitro: from nano- and micro-scale topographies to microfluidic devices.
Thesis

According to the European Brain Council, the annual total cost of brain disorders such as Huntington’s disease (HD) and Parkinson’s disease (PD) in Europe is approximately €386 billion. In order to develop therapies for neurodegenerative diseases, mo... Read More about Fabrication of functional basal ganglia circuitry in vitro: from nano- and micro-scale topographies to microfluidic devices..

Improving the management of lung cancer using mass spectrometry and spectroscopy techniques
Thesis

Lung cancer is a worldwide health problem associated with poor prognosis. The survival at 5 years remains between 5% and 15% in spite of the development of new drugs. One of the main reasons for this is the disease being diagnosed in late stages when... Read More about Improving the management of lung cancer using mass spectrometry and spectroscopy techniques.

Biomarker profiling in rheumatoid arthritis: an investigation of markers of immune dysfunction and their relationship to disease phenotype
Thesis

Rheumatoid arthritis is an autoimmune disease in which various mediators of immune function play a vital role in the pathological process, influencing its development, progression and severity. The aim of this study was to investigate the relation... Read More about Biomarker profiling in rheumatoid arthritis: an investigation of markers of immune dysfunction and their relationship to disease phenotype.

A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum
Thesis

Massive screens of chemical libraries for antimalarial activity have identified thousands of compounds that exhibit sub-micromolar potency against the blood stage of the malaria parasite Plasmodium falciparum. Triaging these compounds to establish pr... Read More about A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum.

Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression
Thesis

Damaged or diseased mature articular cartilage cannot undergo effective tissue repair and due to its avascular, hypocellular nature defects become widespread and painful. No ‘gold standard’ treatment exists for this indication and the ultimate recour... Read More about Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression.