Outputs (39)

Extracellular bacterial production of doped magnetite nanoparticles (2012)
Book Chapter
Pattrick, R. A. D., Coker, V. S., Pearce, C. I., Telling, N. D., van der Laan, G., & Lloyd, J. R. (2012). Extracellular bacterial production of doped magnetite nanoparticles. In Nanoscience: Volume 1: Nanostructures through Chemistry (102-115). Royal Society of Chemistry. https://doi.org/10.1039/9781849734844-00102

Microorganisms have been producing nanoparticles for billions of years and by controlling and tuning this productivity they have the potential to provide novel materials using environmentally friendly manufacturing pathways. Metal-reducing bacteria a... Read More about Extracellular bacterial production of doped magnetite nanoparticles.

A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution (2012)
Journal Article
Strover, L. T., Malmström, J., Laita, O., Reynisson, J., Aydemir, N., Nieuwoudt, M. K., Williams, D. E., Dunbar, P. R., Brimble, M. A., & Travas-Sejdic, J. (2013). A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution. Polymer, 54(4), 1305-1317. https://doi.org/10.1016/j.polymer.2012.11.083

We present the synthesis of a novel conducting polymer (CP) incorporating both pyrrole and thiophene units in its monomer, which is also substituted with an initiator for grafting of sidechains by atom-transfer radical polymerisation (ATRP). The prec... Read More about A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution.

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity (2012)
Journal Article
McCoull, W., Barton, P., Broo, A., Brown, A. J. H., Clarke, D. S., Coope, G., Davies, R. D. M., Dossetter, A. G., Kelly, E. E., Knerr, L., MacFaul, P., Holmes, J. L., Martin, N., Moore, J. E., Morgan, D., Newton, C., Österlund, K., Robb, G. R., Rosevere, E., Selmi, N., …Williams, E. J. (2013). Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity. MedChemComm, 4(2), 456. https://doi.org/10.1039/c2md20340e

A pyrazolo-pyrimidinone based series of growth hormone secretagogue receptor type 1a (GHS-R1a) antagonists and inverse agonists were identified using a scaffold hop from known quinazolinone GHS-R1a modulators. Lipophilicity was reduced to decrease hE... Read More about Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity.

Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis (2012)
Journal Article
(2012). Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis. PloS one, e51350 -?. https://doi.org/10.1371/journal.pone.0051350

Gene delivery technologies to introduce foreign genes into highly differentiated mammalian cells have improved significantly over the last few decades. Relatively new techniques such as magnetic nanoparticle-based gene transfection technology are sho... Read More about Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis.

Oxidative rearrangement of tertiary propargylic alcohols (2012)
Journal Article
Rodríguez, A., & Moran, W. J. (2013). Oxidative rearrangement of tertiary propargylic alcohols. SYNLETT, 24(1), 102-104. https://doi.org/10.1055/s-0032-1317711

An oxidative rearrangement of tertiary alcohols mediated by m-CPBA is described that generates tetrasubstituted alkenes with a carboxylic acid substituent. The mechanism of the reaction is proposed to proceed through epoxidation of the alkyne to form... Read More about Oxidative rearrangement of tertiary propargylic alcohols.

Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice (2012)
Journal Article
Bake, T., Duncan, J. S., Morgan, D. G. A., & Mercer, J. G. (2013). Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice. Journal of Neuroendocrinology, 25(4), 357-371. https://doi.org/10.1111/jne.12008

Meal feeding is a critical issue in the over-consumption of calories leading to human obesity. To investigate the mechanisms involved in the regulation of meal feeding in rodents, we studied a scheduled feeding regime that induces substantial food in... Read More about Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice.

Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study (2012)
Journal Article
White. (2012). Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study. BMC Health Services Research, 425 -?. https://doi.org/10.1186/1472-6963-12-425

BACKGROUND: Non-adherence to prescribed medication is a pervasive problem that can incur serious effects on patients' health outcomes and well-being, and the availability of resources in healthcare systems. This study aimed to develop practical conse... Read More about Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study.

Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells (2012)
Journal Article
Stamelos, V. A., Robinson, E., Redman, C. W., & Richardson, A. (2013). Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells. Gynecologic Oncology, 128(2), 377-382. https://doi.org/10.1016/j.ygyno.2012.11.019

DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems (2012)
Journal Article
Hume, P. A., Brimble, M. A., & Reynisson, J. (2013). DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry, 1005, 9-15. https://doi.org/10.1016/j.comptc.2012.10.022

Mitomycin C is a DNA alkylating agent activated by bioreduction. It has been in clinical use against a range of solid tumours since the 1960s. Its DNA adduct formation mechanism has been extensively studied and it therefore presents an excellent test... Read More about DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems.

Atrial fibrillation in heart failure: an innocent bystander? (2012)
Journal Article
Mamas. (2012). Atrial fibrillation in heart failure: an innocent bystander?. Current Cardiology Reviews, 273 - 280. https://doi.org/10.2174/157340312803760839

Heart failure (HF) and atrial fibrillation (AF) frequently coexist and each complicates the course of the other. The purpose of this review is to analyse the prognostic impact of AF in patients with HF and assess whether there is an advantage in targ... Read More about Atrial fibrillation in heart failure: an innocent bystander?.