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Outputs (39)

Student perceptions of the progress test in two settings and the implications for test deployment (2012)
Journal Article
(2012). Student perceptions of the progress test in two settings and the implications for test deployment. Advances in Health Sciences Education, 573-583. https://doi.org/10.1007/s10459-011-9334-z

Background The Progress Test (PT) was developed to assess student learning within integrated curricula. Whilst it is effective in promoting and rewarding deep approaches to learning in some settings, we hypothesised that implementation of the curricu... Read More about Student perceptions of the progress test in two settings and the implications for test deployment.

Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model (2012)
Journal Article
Rutter, A. V., Chippendale, T. W. E., Yang, Y., Španěl, P., Smith, D., & Sulé-Suso, J. (in press). Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model. Analyst, 138(1), 91-95. https://doi.org/10.1039/c2an36185j

Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2... Read More about Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model.

Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease (2012)
Journal Article
(2012). Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease. PloS one, e47169 -?. https://doi.org/10.1371/journal.pone.0047169

Primary cell transplantation is currently the gold standard for cell replacement in Parkinson's disease. However, the number of donors needed to treat a single patient is high, and the functional outcome is sometimes variable. The present work explor... Read More about Transplanting intact donor tissue enhances dopamine cell survival and the predictability of motor improvements in a rat model of Parkinson's disease.

Microbial Reduction of Arsenic-Doped Schwertmannite by Geobacter sulfurreducens (2012)
Journal Article
Cutting, R. S., Coker, V. S., Telling, N. D., Kimber, R. L., van der Laan, G., Pattrick, R. A. D., Vaughan, D. J., Arenholz, E., & Lloyd, J. R. (2012). Microbial Reduction of Arsenic-Doped Schwertmannite by Geobacter sulfurreducens. Environmental Science and Technology, 46(22), 12591-12599. https://doi.org/10.1021/es204596z

The fate of As(V) during microbial reduction by Geobacter sulfurreducens of Fe(III) in synthetic arsenic-bearing schwertmannites has been investigated. During incubation at pH7, the rate of biological Fe(III) reduction increased with increasing initi... Read More about Microbial Reduction of Arsenic-Doped Schwertmannite by Geobacter sulfurreducens.

Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. (2012)
Journal Article
(2012). Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis. Arthritis Research and Therapy, R204 - ?. https://doi.org/10.1186/ar4042

Matrix metalloproteinases (MMPs) are implicated in the destruction of the joint and have been shown to be strongly associated with inflammation in rheumatoid arthritis (RA). Circulating MMPs have also been associated with cardiovascular disease in th... Read More about Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis..

Antiepileptic drugs and the fetal epigenome (2012)
Journal Article
Emes, R. D., Clifford, H., Haworth, K. E., Farrell, W. E., Fryer, A. A., Carroll, W. D., Ismail, K. M. K., & KM, I. (2013). Antiepileptic drugs and the fetal epigenome. Epilepsia, 54(1), e16-e19. https://doi.org/10.1111/j.1528-1167.2012.03673.x

Antiepileptic drugs (AEDs) can lower maternal folate and increase maternal homocysteine levels, which are known to affect the methyl cycle and hence DNA methylation levels. The influence of in utero exposure to AEDs on fetal DNA methylation was inves... Read More about Antiepileptic drugs and the fetal epigenome.

Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering (2012)
Journal Article
(2012). Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering. Journal of Functional Biomaterials, 642 -687. https://doi.org/10.3390/jfb3030642

Corneal structure is highly organized and unified in architecture with structural and functional integration which mediates transparency and vision. Disease and injury are the second most common cause of blindness affecting over 10 million people wor... Read More about Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering.

Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials (2012)
Journal Article
(2012). Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials. British journal of cancer, 1257-1267. https://doi.org/10.1038/bjc.2012.370

Background:
The National Epirubicin Adjuvant Trial (NEAT) and BR9601 trials tested the benefit of epirubicin when added to cyclophosphamide, methotrexate and 5-fluorouracil (E-CMF) compared with standard CMF in adjuvant chemotherapy for women with e... Read More about Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials.

Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care. (2012)
Journal Article
Jordan. (2012). Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care. BMC Health Services Research, 295 -?. https://doi.org/10.1186/1472-6963-12-295

BACKGROUND: Two of the commonest chronic diseases experienced by older people in the general population are cardiovascular diseases and osteoarthritis. These conditions also commonly co-occur, which is only partly explained by age. Yet, there have be... Read More about Comorbidity Cohort (2C) study: cardiovascular disease severity and comorbid osteoarthritis in primary care..