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Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM (2014)
Journal Article
Deegan, A. J., Cinque, G., Wehbe, K., Konduru, S., & Yang, Y. (2015). Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM. Analytical and Bioanalytical Chemistry, 407(4), 1097-1105. https://doi.org/10.1007/s00216-014-8316-4

One novel tissue engineering approach to mimic in vivo bone formation is the use of aggregate or micromass cultures. Various qualitative and quantitative techniques, such as histochemical staining, protein assay kits and RT-PCR, have been used previo... Read More about Tracking calcification in tissue-engineered bone using synchrotron micro-FTIR and SEM.

Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells (2014)
Journal Article
Malekigorji, M., Hoskins, C., Curtis, T., & Varbiro, G. Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells. Journal of Nanomedicine Research, 1(2), https://doi.org/10.15406/jnmr.2014.01.00010

Treatment of hepatocellular cancer with chemotherapeutic agents has limited success in clinical practice and their efficient IC50 concentration would require extremely high doses of drug administration which could not be tolerated due to systemic sid... Read More about Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells.

Antihypertensive and antibacterial investigations of novel nitric oxide donor compounds (2014)
Journal Article
Hills, D., Mohseni, M., Dowler, J., Greenwood, I., Fielder, M., Pearson, R., & Perumal, D. (2014). Antihypertensive and antibacterial investigations of novel nitric oxide donor compounds. Nitric Oxide: Biology and Chemistry, 42, 126. https://doi.org/10.1016/j.niox.2014.09.082

Nitric oxide, being a free radical, has a unique biological chemistry that since its elucidation as a signalling molecule in the cardiovascular system has been implicated in diverse biological functions ranging from insulin secretion, nociception and... Read More about Antihypertensive and antibacterial investigations of novel nitric oxide donor compounds.

The role of drug transporters in the kidney: lessons from tenofovir (2014)
Journal Article
(2014). The role of drug transporters in the kidney: lessons from tenofovir. Frontiers in Pharmacology, https://doi.org/10.3389/fphar.2014.00248

Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients. However, long-term kidney toxicity is now acknowledged as a modest but significant ri... Read More about The role of drug transporters in the kidney: lessons from tenofovir.

'I wouldn't push that further because I don't want to lose her': a multiperspective qualitative study of behaviour change for long-term conditions in primary care. (2014)
Journal Article
Chew-Graham, C. (2014). 'I wouldn't push that further because I don't want to lose her': a multiperspective qualitative study of behaviour change for long-term conditions in primary care. Health Expectations, 1995 -2010. https://doi.org/10.1111/hex.12304

BACKGROUND: Health outcomes for long-term conditions (LTCs) can be improved by lifestyle, dietary and condition management-related behaviour change. Primary care is an important setting for behaviour change work. Practitioners have identified barrier... Read More about 'I wouldn't push that further because I don't want to lose her': a multiperspective qualitative study of behaviour change for long-term conditions in primary care..

Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation (2014)
Journal Article
Robinson, E., Leung, E., Matuszek, A. M., Krogsgaard-Larsen, N., Furkert, D. P., Brimble, M. A., …Reynisson, J. (in press). Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation. MedChemComm, 6(1), 239-246. https://doi.org/10.1039/c4md00420e

Two hit compounds (14 and 62) were identified using virtual high throughput screening (vHTS) inhibiting the autophagy process in A2780 ovarian cancer cells. The expression levels of the LC3-II and p62 autophagy marker proteins were monitored using We... Read More about Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation.

Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs (2014)
Journal Article
Dunphy, S. E., Bratt, J. A., Akram, K. M., Forsyth, N. R., & El Haj, A. J. (2014). Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs. Journal of the Mechanical Behavior of Biomedical Materials, 38, 251-259. https://doi.org/10.1016/j.jmbbm.2014.04.005

In this study, collagen–elastin constructs were prepared with the aim of producing a material capable of mimicking the mechanical properties of a single alveolar wall. Collagen has been used in a wide range of tissue engineering applications; however... Read More about Hydrogels for lung tissue engineering: Biomechanical properties of thin collagen–elastin constructs.