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Outputs (158)

Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development (2015)
Journal Article
Horrocks. (2015). Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development. Parasites and Vectors, 81. https://doi.org/10.1186/s13071-015-0701-0

Background Over 2700 genes are subject to stage-specific regulation during the intraerythrocytic development of the human malaria parasite Plasmodium falciparum. Bioinformatic analyses have identified a large number of over-represented motifs in the... Read More about Triaging informative cis -regulatory elements for the combinatorial control of temporal gene expression during Plasmodium falciparum intraerythrocytic development.

Development of an in vitro model for studying the penetration of chemicals through compromised skin. (2015)
Journal Article
(2015). Development of an in vitro model for studying the penetration of chemicals through compromised skin. Toxicology in Vitro, 176 - 181. https://doi.org/10.1016/j.tiv.2014.09.012

The conventional safety approach that includes dermal absorption of pharmaceutical or consumer products uses models that are based on intact skin. However, when products are intended for application to skin with a less effective barrier, such as in n... Read More about Development of an in vitro model for studying the penetration of chemicals through compromised skin..

Socioeconomic deprivation and survival after stroke in China: a systematic literature review and a new population-based cohort study (2015)
Journal Article
Chen, R., Hu, Z., Chen, R., Zhang, D., Xu, L., Wang, J., & Wei, L. (2015). Socioeconomic deprivation and survival after stroke in China: a systematic literature review and a new population-based cohort study. BMJ Open, 5(1), Article e005688. https://doi.org/10.1136/bmjopen-2014-005688

OBJECTIVE: To assess the association of socioeconomic deprivation (SED) with survival after stroke in China. DESIGN: A systematic literature review and a new population-based cohort study. SETTING AND PARTICIPANTS: In urban and rural communities in A... Read More about Socioeconomic deprivation and survival after stroke in China: a systematic literature review and a new population-based cohort study.

Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 (2015)
Journal Article
(2015). Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proceedings of the National Academy of Sciences of the United States of America, 755-760. https://doi.org/10.1073/pnas.1416611112

Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Muc... Read More about Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.

Determination of formulation factors that affect oral medicines acceptability in a domicilliary paediatric population (2015)
Journal Article
Venables. (2015). Determination of formulation factors that affect oral medicines acceptability in a domicilliary paediatric population. International Journal of Pharmaceutics, 55 - 62. https://doi.org/10.1016/j.ijpharm.2015.01.023

Acceptability of medicines for children is a challenge, yet critical to ensure adherence to treatment. There is very little literature on formulation factors that influence acceptability of medicines, particularly in the domiciliary environment. This... Read More about Determination of formulation factors that affect oral medicines acceptability in a domicilliary paediatric population.

The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens (2015)
Journal Article
Gilchrist. (2015). The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens. Analytical Methods, 818 -824. https://doi.org/10.1039/c4ay02981j

There is interest in the development of exhaled breath tests for the detection of lower airway infection in children with cystic fibrosis. The first stage of this process is the identification of volatile organic compounds (VOCs) released into the ga... Read More about The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens.

The application of tribology in assessing texture perception of oral liquid medicine (2015)
Journal Article
Venables. (2015). The application of tribology in assessing texture perception of oral liquid medicine. International Journal of Pharmaceutics, 277 - 281. https://doi.org/10.1016/j.ijpharm.2015.01.004

The palatability of medicines is likely to have a significant impact on patient adherence and consequently, on the safety and efficacy of a medicinal product. Palatability encompasses properties of medicines not limited to taste including swallowabil... Read More about The application of tribology in assessing texture perception of oral liquid medicine.