Outputs (158)

Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer (2015)
Journal Article
(2015). Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer. Journal of Cancer Research and Clinical Oncology, 611-618. https://doi.org/10.1007/s00432-015-2074-3

Purpose
Mevalonate pathway inhibitors are potentially useful chemotherapeutic agents showing growth inhibition and pro-apoptotic effects in cancer cells. The effects of statins and bisphosphonates on cancer growth are attributed to a reduction in pr... Read More about Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer.

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article
Gilchrist, F. J., Belcher, J., Jones, A. M., Smith, D., Smyth, A. R., Southern, K. W., Španěl, P., Kevin Webb, A., & Lenney, W. (2015). Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis. ERJ Open Research, 1(2), https://doi.org/10.1183/23120541.00044-2015

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Protein engineering of a new recombinant peptide to increase the surface contact angle of stainless steel (2015)
Journal Article
Ren, X. Y., Bai, X. Q., Yuan, C. Q., Yang, Y., Xie, H., Cao, P., Ma, C. Y., Wang, X. J., & Yan, X. P. (in press). Protein engineering of a new recombinant peptide to increase the surface contact angle of stainless steel. RSC advances, 5(123), 101309-101318. https://doi.org/10.1039/c5ra13855h

A predictive multi-linear regression model for organic micropollutants, based on a laboratory-scale column study simulating the river bank filtration process (2015)
Journal Article
Bertelkamp, C., Verliefde, A., Reynisson, J., Singhal, N., Cabo, A., de Jonge, M., & van der Hoek, J. (2016). A predictive multi-linear regression model for organic micropollutants, based on a laboratory-scale column study simulating the river bank filtration process. Journal of Hazardous Materials, 304, 502-511. https://doi.org/10.1016/j.jhazmat.2015.11.003

This study investigated relationships between OMP biodegradation rates and the functional groups present in the chemical structure of a mixture of 31 OMPs. OMP biodegradation rates were determined from lab-scale columns filled with soil from RBF site... Read More about A predictive multi-linear regression model for organic micropollutants, based on a laboratory-scale column study simulating the river bank filtration process.

Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom (2015)
Journal Article
Curtis, A., Malekigorji, M., Holman, J., Skidmore, M., & Hoskins, C. (2015). Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom. Journal of Nanomedicine and Nanotechnology, 6(6), https://doi.org/10.4172/2157-7439.1000335

Hybrid iron oxide-gold nanoparticles (HNPs) have shown potential in cancer therapy as agents for tumour ablation and thermal switches for targeted drug release. Heat generation occurs by exploitation of the surface plasmon resonance of the gold coati... Read More about Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom.

From raw data to data-analysis for magnetic resonance spectroscopy – the missing link: jMRUI2XML (2015)
Journal Article
(2015). From raw data to data-analysis for magnetic resonance spectroscopy – the missing link: jMRUI2XML. BMC Bioinformatics, 378 -378. https://doi.org/10.1186/s12859-015-0796-5

Background
Magnetic resonance spectroscopy provides metabolic information about living tissues in a non-invasive way. However, there are only few multi-centre clinical studies, mostly performed on a single scanner model or data format, as there is n... Read More about From raw data to data-analysis for magnetic resonance spectroscopy – the missing link: jMRUI2XML.

Image analysis and quantification of tissue scaffolds (2015)
Book Chapter
Yang, Y., & Wimpenny, I. (2015). Image analysis and quantification of tissue scaffolds. In Characterisation and Design of Tissue Scaffolds (201-223). Elsevier. https://doi.org/10.1016/b978-1-78242-087-3.00009-2

If you can measure something, then you can improve it. Measurement of the structural and functional parameters of tissue-engineering scaffolds is important in the context of better scaffold design, regulation of cellular activities, and the predictio... Read More about Image analysis and quantification of tissue scaffolds.

Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest (2015)
Journal Article
McCarthy, H. S., Richardson, J. B., Parker, J. C., & Roberts, S. (2015). Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest. Cartilage, 7(1), 7-15. https://doi.org/10.1177/1947603515607963

Objective
To establish if harvesting cartilage to source chondrocytes for autologous chondrocyte implantation (ACI) results in donor site morbidity.

Design
Twenty-three patients underwent ACI for chondral defects of either the ankle or the hip.... Read More about Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest.

Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors (2015)
Journal Article
(2015). Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors. Biogerontology, 619 - 639. https://doi.org/10.1007/s10522-015-9621-9

We have previously highlighted the ability of testosterone (T) to improve differentiation and myotube hypertrophy in fusion impaired myoblasts that display reduced myotube hypertrophy via multiple population doublings (PD) versus their parental contr... Read More about Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors.

Defining Known Drug Space Using DFT (2015)
Journal Article
Matuszek, A. M., & Reynisson, J. (2016). Defining Known Drug Space Using DFT. Molecular Informatics, 35(2), 46-53. https://doi.org/10.1002/minf.201500105

A density functional theory (DFT) study was performed on a collection of clinically approved drugs, or Known Drug Space (KDS), to determine the statistical distribution of four properties: dipole moment (DM), polarisability (POL), ionisation potentia... Read More about Defining Known Drug Space Using DFT.