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Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Presentation / Conference Contribution
Uche, F. I., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. W. Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine

Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis. Drug Safety, 229-240. https://doi.org/10.1007/s40264-016-0481-2

Introduction
Thienopyridines are a class of antiplatelet drugs widely used in cardiovascular disease prevention and treatment. A recent concern has come to light regarding the safety of thienopyridines because of the possible risk of malignancy. We... Read More about Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis.

The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood (2016)
Journal Article
Hulme, C., Brown, S., Fuller, H., Riddell, J., Osman, A., Chowdhury, J., Kumar, N., Johnson, W., & Wright, K. (2017). The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood. Spinal Cord, 55, 114-125. https://doi.org/10.1038/sc.2016.174

Objectives:
The identification of prognostic biomarkers of spinal cord injury (SCI) will help to assign SCI patients to the correct treatment and rehabilitation regimes. Further, the detection of biomarkers that predict permanent neurological outcom... Read More about The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood.

A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials (2016)
Journal Article
Horrocks. (2016). A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials. Journal of Antimicrobial Chemotherapy, 717-726. https://doi.org/10.1093/jac/dkw449

Objectives: A future treatment for uncomplicated malaria will contain at least one component that exerts a rapid rate of kill. We describe here the validation and application of a simple, robust and rapid bioluminescence-based assay for the determina... Read More about A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials.

Optimization of supercritical extraction of galegine from Galega officinalis L.: Neural network modeling and experimental optimization via response surface methodology (2016)
Journal Article
Davoodi, P., Ghoreishi, S. M., & Hedayati, A. (2017). Optimization of supercritical extraction of galegine from Galega officinalis L.: Neural network modeling and experimental optimization via response surface methodology. Korean Journal of Chemical Engineering, 34(3), 854-865. https://doi.org/10.1007/s11814-016-0304-2

Supercritical CO2 extraction of galegine from Galega officinalis L. was carried out under different operating conditions of temperature (35-55 °C), pressure (10-30MPa), dynamic extraction time (30-150min), CO2 flow rate (0.5-2.5 mL/min) and constant... Read More about Optimization of supercritical extraction of galegine from Galega officinalis L.: Neural network modeling and experimental optimization via response surface methodology.

Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies (2016)
Journal Article
Owen, S., Jones, P., Caterson, B., Shirran, S., Fuller, H., Botting, C., & Roberts, S. (2016). Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies. Bioscience Reports, https://doi.org/10.1042/BSR20160465

This paper reports the perplexing results that came about because of seriously impure commercially available reagents. Commercial reagents and chemicals are routinely ordered by scientists and are expected to have been rigorously assessed for their p... Read More about Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies.

Elucidation of the Physicochemical Properties Ruling the Colloidal Stability of Iron Oxide Nanoparticles under Physiological Conditions (2016)
Journal Article
Aires, A., Cabrera, D., Alonso-Pardo, L. C., Cortajarena, A. L., & Teran, F. J. (2017). Elucidation of the Physicochemical Properties Ruling the Colloidal Stability of Iron Oxide Nanoparticles under Physiological Conditions. ChemNanoMat, 3(3), 183-189. https://doi.org/10.1002/cnma.201600333

Nanotechnology has brought countless novel applications regarding therapeutic, diagnostic, and sensing innovations. In particular, nanoparticle engineering enables the synthesis of nanocrystals with customized physical, chemical, and biological activ... Read More about Elucidation of the Physicochemical Properties Ruling the Colloidal Stability of Iron Oxide Nanoparticles under Physiological Conditions.