Outputs (243)

Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis (2016)
Journal Article
Garcia, J., Wei, W., Runhaar, J., Wright, K., Mennan, C., Roberts, S., …Bastiaansen-Jenniskens, Y. (2016). Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis. Osteoarthritis and Cartilage, 24(S1), S334-S335. https://doi.org/10.1016/j.joca.2016.01.599

Purpose: Obesity is known to be a risk factor for the development of osteoarthritis (OA). Obesity is accompanied by adipocyte hypertrophy and elevated inflammation in subcutaneous and visceral adipose tissue. The infrapatellar fat pad (IPFP) is an ad... Read More about Obesity does not affect the size of infrapatellar fat pad adipocytes: implications for the pathogenesis of knee osteoarthritis.

OCT as a convenient tool to assess the quality and application of organotypic retinal samples (2016)
Journal Article
Gater, R., Khoshnaw, N., Nguyen, D., El Haj, A. J., & Yang, Y. (2016). OCT as a convenient tool to assess the quality and application of organotypic retinal samples. Proceedings of SPIE, 9707, https://doi.org/10.1117/12.2213509

Eye diseases such as macular degeneration and glaucoma have profound consequences on the quality of human life. Without treatment, these diseases can lead to loss of sight. To develop better treatments for retinal diseases, including cell therapies a... Read More about OCT as a convenient tool to assess the quality and application of organotypic retinal samples.

Effects of inter- and intra-aggregate magnetic dipolar interactions on the magnetic heating efficiency of iron oxide nanoparticles (2016)
Journal Article
Ovejero, J. G., Cabrera, D., Carrey, J., Valdivielso, T., Salas, G., & Teran, F. J. (in press). Effects of inter- and intra-aggregate magnetic dipolar interactions on the magnetic heating efficiency of iron oxide nanoparticles. Physical Chemistry Chemical Physics, 18(16), 10954-10963. https://doi.org/10.1039/c6cp00468g

Iron oxide nanoparticles have found an increasing number of biomedical applications as sensing or trapping platforms and therapeutic and/or diagnostic agents. Most of these applications are based on their magnetic properties, which may vary depending... Read More about Effects of inter- and intra-aggregate magnetic dipolar interactions on the magnetic heating efficiency of iron oxide nanoparticles.

Explaining inequalities in receipt of care in the older patient with acute coronary syndrome (2016)
Journal Article
Mamas. (2016). Explaining inequalities in receipt of care in the older patient with acute coronary syndrome. European Heart Journal - Quality of Care and Clinical Outcomes, 59-61. https://doi.org/10.1093/ehjqcco/qcw011

The world's population is ageing and patients with acute coronary syndromes (ACS) are presenting later in life such that a third or more are now aged =70.1 ACS mortality rates are higher in older patients,1 and absolute benefits of treatment are, the... Read More about Explaining inequalities in receipt of care in the older patient with acute coronary syndrome.

Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells (2016)
Journal Article
Wilson, E., Garton, M., & Fuller, H. (2016). Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells. Epilepsy Research, 97-101. https://doi.org/10.1016/j.eplepsyres.2016.03.002

Phenytoin is an antiepileptic drug used in the management of partial and tonic-clonic seizures. In previous studies we have shown that valproate, another antiepileptic drug, reduced the amount of two key bone proteins, pro-collagen I and osteonectin... Read More about Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells.

Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. (2016)
Journal Article
Bhattacharjee, A., McCarthy, H. S., Tins, B., Roberts, S., Kuiper, J. H., Harrison, P. E., & Richardson, J. B. (2016). Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. American Journal of Sports Medicine, 44(5), 1249 - 1259. https://doi.org/10.1177/0363546516631739

BACKGROUND: Structural and functional outcome of bone graft with first- or second-generation autologous chondrocyte implantation (ACI) in treating cartilage and subchondral bone defect has not been reported previously. PURPOSE: To evaluate the outcom... Read More about Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee..

An audit on the use of chaperones during intimate patient examinations (2016)
Journal Article
(2016). An audit on the use of chaperones during intimate patient examinations. https://doi.org/10.1016/j.amsu.2016.03.005

Background The general medical council stipulate all intimate examinations should be chaperoned, and their identity documented within patients' notes. We decided to audit our surgical unit for compliance to these guidelines. Methods A prospectiv... Read More about An audit on the use of chaperones during intimate patient examinations.

Pigtail catheter "propping" for MitraClip percutaneous transcatheter mitral valve repair. (2016)
Journal Article
(2016). Pigtail catheter "propping" for MitraClip percutaneous transcatheter mitral valve repair. Catheterization & Cardiovascular Interventions, 316-318. https://doi.org/10.1002/ccd.26288

In recent years percutaneous therapy has emerged as a feasible and effective option for the treatment of mitral regurgitation, particularly in cases where the risks of conventional cardiac surgery are prohibitively high. To date the most widely used... Read More about Pigtail catheter "propping" for MitraClip percutaneous transcatheter mitral valve repair..

Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women (2016)
Journal Article
Solis-Trapala. (2016). Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women. The Journal of Nutrition, 846-854. https://doi.org/10.3945/jn.115.224485

Background: There is increasing recognition of complex interrelations between the endocrine functions of bone and fat tissues or organs. Objective: The objective was to describe nonmechanical and mechanical links between metabolic factors, body co... Read More about Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors, Body Composition, and Bone in Healthy Postmenopausal Women.

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. (2016)
Journal Article
Stamelos, V. A., Fisher, N., Bamrah, H., Voisey, C., Price, J. C., Farrell, W. E., …Richardson, A. (in press). The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. PloS one, e0150696 - ?. https://doi.org/10.1371/journal.pone.0150696

Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that... Read More about The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization..