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Outputs (202)

Hydroxypropylmethacrylamide based thermoresponsive magnetomicelles for controllable drug delivery in pancreatic cancer (2018)
Thesis
Alsuraifi, A. T. Y. (2018). Hydroxypropylmethacrylamide based thermoresponsive magnetomicelles for controllable drug delivery in pancreatic cancer. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412030

Thermo-responsive polymers are a class of smart polymers that respond to change in temperature. This property makes this type of polymers useful materials in a wide range of applications especially, in the field of drug delivery system. Polymers, whi... Read More about Hydroxypropylmethacrylamide based thermoresponsive magnetomicelles for controllable drug delivery in pancreatic cancer.

Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis (2018)
Thesis
Ditchfield, N. (2018). Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417942

Kidney damage in cystic fibrosis (CF) patients is most commonly caused by antibiotics, such as aminoglycosides, which are used to treat Pseudomonas aeruginosa (PA). I conducted a survey of UK CF centres which showed a high rate of use of aminoglycosi... Read More about Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis.

Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. (2018). Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.

A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials (2018)
Thesis
Potts, J. E. (2018). A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412318

Most analyses in stroke clinical trials assess the primary outcome at a single time point and do not consider conducting a longitudinal analysis, even when the outcome has been recorded at several time points. Efforts to improve the quality of statis... Read More about A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials.

Biosimilars: market analysis and survey of factors influencing prescribing (2018)
Thesis
Aladul, M. (2018). Biosimilars: market analysis and survey of factors influencing prescribing. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412316

Background: Biological medicines are effective but expensive options for treating patients with chronic and life-threatening diseases unresponsive to conventional small molecule medicines. The importance of biosimilars as an alternative to expensive... Read More about Biosimilars: market analysis and survey of factors influencing prescribing.

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article
Holmes, A. M., Heylings, J. R., Wan, K., & Moss, G. P. (2019). Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. International Journal of Antimicrobial Agents, 53(4), 500-507. https://doi.org/10.1016/j.ijantimicag.2018.12.012

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. (2018)
Journal Article
Slater, N., Rowley, C., Venables, R., White, S., & Frisher, M. (2018). Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. BMJ Open, 8(12), https://doi.org/10.1136/bmjopen-2018-025394

OBJECTIVES: Conflicting results have been reported when the associations between metabolic health, obesity and depression were examined previously. The primary aim of this study was to determine whether metabolic health or obesity are independently a... Read More about Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up..

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life (2018)
Journal Article
(2019). The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life. Seminars in Arthritis and Rheumatism, 49(1), 20-26. https://doi.org/10.1016/j.semarthrit.2018.12.006

Objective
Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them... Read More about The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life.

Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database (2018)
Journal Article
Mamas. (2018). Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 2480-2491. https://doi.org/10.1016/j.jcin.2018.09.035

Objectives
Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected left main stem percutaneou... Read More about Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database.