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Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. (2018)
Journal Article
Baker, M., Byrne, H., Chalmers, J., Gardner, P., Goodacre, R., Henderson, A., …Sule-Suso, J. (2018). Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. Analyst, 1735 - 1757. https://doi.org/10.1039/C7AN01871A

Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolution... Read More about Clinical applications of infrared and Raman spectroscopy: state of play and future challenges..

Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation (2018)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018). Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation. Osteoarthritis and Cartilage, 26(S1), S167. https://doi.org/10.1016/j.joca.2018.02.363

Background: Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternat... Read More about Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation.

Assessing The Characteristics Of Human Mesenchymal Stromal Cells Derived From Bone Marrow And Umbilical Cord Following Expansion In The Quantum® Hollow-fibre Bioreactor System (2018)
Journal Article
Mennan, C., Roberts, S., Garcia, J., Hulme, C., & Wright, K. (2018). Assessing The Characteristics Of Human Mesenchymal Stromal Cells Derived From Bone Marrow And Umbilical Cord Following Expansion In The Quantum® Hollow-fibre Bioreactor System. Osteoarthritis and Cartilage, 26(S1), S146-S147. https://doi.org/10.1016/j.joca.2018.02.316

No abstract

Assessment of candidate predictive protein biomarkers for microfracture and osteotomy (2018)
Journal Article
Hulme, C., Richardson, J., Gallacher, P., Roberts, S., & Wright, K. (2018). Assessment of candidate predictive protein biomarkers for microfracture and osteotomy. Osteoarthritis and Cartilage, 26(S1), S191-S192. https://doi.org/10.1016/j.joca.2018.02.410

PlumX Metrics Purpose: Biomarkers that can predict clinical outcome for surgeries to prevent the progression of osteoarthritis (OA) are needed to ensure patients can be better stratified to receive the most appropriate treatment. We have previousl... Read More about Assessment of candidate predictive protein biomarkers for microfracture and osteotomy.

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy (2018)
Journal Article
Sykes, J., Kuiper, J., Richardson, J., Wright, K., & Kuiper, N. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Osteoarthritis and Cartilage, 26(S1), https://doi.org/10.1016/j.joca.2018.02.221

Purpose High hopes have been pinned on regenerative medicine strategies to meet the challenge of preventing the progression to osteoarthritis, in particular autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy.

Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy (2018)
Journal Article
Al-Shakarci, W., Alsuraifi, A., Abed, M., Abdullah, M., Hoskins, C., Richardson, A., & Curtis, A. (2018). Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy. Pharmaceutics, 48. https://doi.org/10.3390/pharmaceutics10020048

Hepatocellular carcinoma is an aggressive form of liver cancer that displays minimal symptoms until its late stages. Unfortunately, patient prognosis still remains poor with only 10% of patients surviving more than five years after diagnosis. Current... Read More about Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy.

Managing Clinical Heterogeneity: An Argument for Benefit-Based Action Limits (2018)
Journal Article
(2018). Managing Clinical Heterogeneity: An Argument for Benefit-Based Action Limits. https://doi.org/10.1115/1.4039561

The use of reference ranges is well established in medical practice and research. Classically, a range would be derived from the local healthy population and matched in age, gender, and other characteristics to the patients under investigation. Howev... Read More about Managing Clinical Heterogeneity: An Argument for Benefit-Based Action Limits.

Same-day Inter-Facility Transfer for Percutaneous Coronary Intervention (2018)
Journal Article
Israeli, Z., Lavi, S., Bertand, O. F., & Mamas, M. (2018). Same-day Inter-Facility Transfer for Percutaneous Coronary Intervention. Journal of Interventional Cardiology, 230-235. https://doi.org/10.1111/joic.12486

Background: The use of radial approach for coronary angiography, followed by same-day inter-facility transfer for percutaneous coronary intervention (PCI) has not yet been evaluated. We sought to assess the safety and feasibility of using the transra... Read More about Same-day Inter-Facility Transfer for Percutaneous Coronary Intervention.