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Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining (2018)
Journal Article
(2018). Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining. Scientific Data, https://doi.org/10.1038/sdata.2018.213

DNA methylation is an important epigenetic modification that can regulate gene expression following environmental encounters without changes to the genetic code. Using Infinium MethylationEPIC BeadChip Arrays (850,000 CpG sites) we analysed for the f... Read More about Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining.

Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells (2018)
Journal Article
(2018). Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells. Journal of Tissue Engineering, 2041731418808695 - ?. https://doi.org/10.1177/2041731418808695

Magnetic ion channel activation technology uses superparamagnetic nanoparticles conjugated with targeting antibodies to apply mechanical force directly to stretch-activated ion channels on the cell surface, stimulating mechanotransduction and downstr... Read More about Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells.

Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy. (2018)
Journal Article
Kadam, U. T., Roberts, I., White, S., Bednall, R., Khunti, K., Nilsson, P. M., & Lawson, C. A. (2019). Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy. Journal of Clinical Epidemiology, 106, 98-107. https://doi.org/10.1016/j.jclinepi.2018.10.014

With older and ageing populations, patients experience multiple chronic diseases at the same time. Individual chronic disease guidelines often recommend pharmacological therapies as a key intervention, resulting in patients being prescribed multiple... Read More about Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy..

Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. (2018)
Journal Article
Gilchrist. (2018). Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. BMJ Paediatrics Open, e000367 - ?. https://doi.org/10.1136/bmjpo-2018-000367

Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocol... Read More about Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres..

Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation (2018)
Journal Article
(2018). Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation. Scientific reports, https://doi.org/10.1038/s41598-018-33281-6

Nebulin is a very large protein required for assembly of the contractile machinery in muscle. Mutations in the nebulin gene NEB are a common cause of nemaline myopathy. Nebulin mRNA is alternatively-spliced so that each mRNA contains either exon 143... Read More about Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation.

Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomised controlled trial (2018)
Journal Article
Velikova, G., Jane Williams, L., Willis, S., Michael Dixon, J., Loncaster, J., Hatton, M., …Yuille, F. (2018). Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomised controlled trial. Lancet Oncology, 19(11), 1516 - 1529. https://doi.org/10.1016/s1470-2045%2818%2930515-1

Background Postmastectomy radiotherapy in patients with four or more positive axillary nodes reduces breast cancer mortality, but its role in patients with one to three involved nodes is controversial. We assessed the effects of postmastectomy radio... Read More about Quality of life after postmastectomy radiotherapy in patients with intermediate-risk breast cancer (SUPREMO): 2-year follow-up results of a randomised controlled trial.

Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors. (2018)
Journal Article
Chen. (2018). Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors. Frontiers in Cell and Developmental Biology, -. https://doi.org/10.3389/fcell.2018.00132

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures optimum ATP production and cell integrity, and is associated bo... Read More about Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors..

Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport (2018)
Journal Article
Davies, & Lambie. (2018). Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport. Clinical Journal of the American Society of Nephrology, 1526-1533. https://doi.org/10.2215/%3FCJN.02380218

Background and objectives The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because bio... Read More about Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport.

Transradial Approach for Left Ventricular Endomyocardial Biopsy (2018)
Journal Article
Mamas. (2018). Transradial Approach for Left Ventricular Endomyocardial Biopsy. Canadian Journal of Cardiology, 1283-1288. https://doi.org/10.1016/j.cjca.2018.05.007

Background Left ventricular endomyocardial biopsy (LV-EMB) may offer a superior diagnostic yield compared with right ventricular endomyocardial biopsy (RV-EMB) in conditions predominantly affecting the LV but is underused compared with RV-EMB. Despi... Read More about Transradial Approach for Left Ventricular Endomyocardial Biopsy.