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Outputs (187)

Exploring the effects of gestational diabetes on placental membrane derived stem cells (2019)
Thesis
Chen, L. (2019). Exploring the effects of gestational diabetes on placental membrane derived stem cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414443

The progression of regenerative medicine and advanced cell banking technology provide the hope of using perinatal tissue-derived autologous MSCs for personalised medicine. Mesenchymal stem cells (MSCs) derived from placenta, with the advantages of be... Read More about Exploring the effects of gestational diabetes on placental membrane derived stem cells.

Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts (2019)
Journal Article
Horrocks. (2019). Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts. Frontiers in Plant Science, https://doi.org/10.3389/fpls.2019.00984

Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory trichomes, is the active ingredient in the most effective treatment for uncomplicated malaria caused by Plasmodium falciparum parasites. Other metabolites in A. annu... Read More about Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts.

Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. (2019)
Journal Article
Lermyte, F., Everett, J., Lam, Y., Wootton, C., Brooks, J., Barrow, M., …Collingwood, J. (2019). Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. Journal of The American Society for Mass Spectrometry, 30(10), 2123-2134. https://doi.org/10.1007/s13361-019-02283-7

Native top-down mass spectrometry is a fast, robust biophysical technique that can provide molecular-scale information on the interaction between proteins or peptides and ligands, including metal cations. Here we have analyzed complexes of the full-l... Read More about Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry..

Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis (2019)
Journal Article
Aldulaimi, O., Drijfhout, F., Uche, F. I., Horrocks, P., & Li, W. (2019). Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis. BMC Complementary and Alternative Medicine, 183 -?. https://doi.org/10.1186/s12906-019-2589-2

BACKGROUND Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts showed potent in vitro antiba... Read More about Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis.

Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates (2019)
Journal Article
Yang. (2019). Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates. https://doi.org/10.1016/j.bj.2019.01.003

Background Micro-mass culturing or cellular aggregation is an effective method used to form mineralised bone tissue. Poor core cell viability, however, is often an impeding characteristic of large micro-mass cultures, and equally for large tissue-eng... Read More about Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates.

Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis (2019)
Journal Article
Eustace, A., McNaughton, E., King, S., Kehoe, O., Kungl, A., Mattey, D., …Middleton, J. (2019). Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis. Arthritis Research and Therapy, 21, Article 172. https://doi.org/10.1186/s13075-019-1939-2

Background Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in rheumatoid arthritis patients... Read More about Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis.

A cadaveric study quantifying the anatomical landmarks of the facial artery and its parapharyngeal branches for safe transoral surgery. (2019)
Journal Article
(2019). A cadaveric study quantifying the anatomical landmarks of the facial artery and its parapharyngeal branches for safe transoral surgery. Head and Neck, https://doi.org/10.1002/hed.25862

BACKGROUND: Hemorrhage remains a major potential risk when performing any form of transoral surgery. This is the first study to focus on the location of the facial artery "bulb" (FaB) and its tonsillar branches within the parapharyngeal space (PPS) f... Read More about A cadaveric study quantifying the anatomical landmarks of the facial artery and its parapharyngeal branches for safe transoral surgery..

The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges (2019)
Journal Article
Reynisson. (2019). The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges. Applied Sciences, 2767 -2767. https://doi.org/10.3390/app9132767

Eleven amide and thioamide derivatives with monoterpene and adamantine substituents were synthesised. They were tested for their activity against the tyrosyl-DNA phosphodiesterase 1 DNA (Tdp1) repair enzyme with the most potent compound 47a, having a... Read More about The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges.