Outputs (141)

Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. (2020)
Journal Article
Kuiper. (2020). Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. https://doi.org/10.1142/S2424835520500484

Background: Pulvertaft Weave (PTW) is an established method of tenorrhapy in tendon transfers. Previous studies have suggested that a Side-to-Side (STS) tenorrhapy is easier to perform has the same advantages and has greater load to failure, ultimate... Read More about Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons..

The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation (2020)
Thesis
Richardson, C. L. The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation. (Thesis). Keele University. https://keele-repository.worktribe.com/output/418968

Introduction
Patients commencing new medications, particularly those that are high risk such as non-vitamin K oral anticoagulants (NOACs), require counselling to ensure safe, effective and empowering use of the medicine. Pharmacists are well placed... Read More about The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation.

Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex (2020)
Thesis
Harvey, L. A. Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex. (Thesis). Keele University. https://keele-repository.worktribe.com/output/418966

Projection neurons located in the superficial layers of the entorhinal cortex provide the hippocampus with nearly all its sensory input. This innervation occurs via multiple discrete pathways to different targets within the hippocampus, including the... Read More about Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex.

Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. (2020)
Journal Article
Gómez-Gálvez, Y., & Gates, M. (2020). Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. Journal of Neuroscience Methods, 109065 - ?. https://doi.org/10.1016/j.jneumeth.2020.109065

BACKGROUND: Primary embryonic ventral mesencephalic (VM) cultures are a high throughput tool for understanding and manipulating dopamine neurons, to study the mechanisms that trigger their degeneration during Parkinson's disease (PD), and to test new... Read More about Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons..

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani  , I., Rudd  , T. R., Elli  , S., Gandhi  , N. S., Guimond  , S. E., Miller, G. J., Meneghetti, M. C., Nader, H. B., Li, Y., Nunes, Q. M., Procter, P., Mancini, N., Clementi, M., Bisio, A., Forsyth, N. R., Ferro, V., Turnbull  , J. E., Guerrini  , M., …Skidmore   , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A. H., Aziz, A., Alansari, R., Ferry, N., Krstic-Demonacos, M., & Ragazzon, P. (2020). Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note. (2020)
Journal Article
(2020). Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note. Medicina, https://doi.org/10.3390/medicina56120715

Purpose: Nowadays, surgical treatment of acute avulsions of the Achilles tendon represents a hard challenge. There is often the possibility that the calcaneus remains completely uncovered from the tendon, making the reinsertion of its distal stub com... Read More about Less Invasive Fixation of Acute Avulsions of the Achilles Tendon: A Technical Note..

Optimized construction of a full thickness human skin equivalent using 3D bioprinting and a PCL/collagen dermal scaffold (2020)
Journal Article
Ramasamy, S., Davoodi, P., Vijayavenkataraman, S., Teoh, J. H., Thamizhchelvan, A. M., Robinson, K. S., Wu, B., Fuh, J. Y., DiColandrea, T., Zhao, H., Lane, E. B., & Wang, C.-H. (2021). Optimized construction of a full thickness human skin equivalent using 3D bioprinting and a PCL/collagen dermal scaffold. Bioprinting, 21, Article e00123. https://doi.org/10.1016/j.bprint.2020.e00123

Validation of a hospital clinical pharmacy workforce calculator: A methodology for pharmacy? (2020)
Journal Article
Bednall, R., White, S., Mills, E., & Thomson, S. (2021). Validation of a hospital clinical pharmacy workforce calculator: A methodology for pharmacy?. International Journal of Clinical Practice, 75(5), Article e13932. https://doi.org/10.1111/ijcp.13932

The benefits of clinical pharmacy services are established within hospital practice but staff numbers required for service delivery are not well described and staffing levels vary. The need for a consistent, objective method of determining staffing l... Read More about Validation of a hospital clinical pharmacy workforce calculator: A methodology for pharmacy?.

Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues (2020)
Journal Article
Wang, J., Roberts, S., Kuiper, J., Zhang, W., Garcia, J., Cui, Z., & Wright, K. (2020). Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues. Scientific reports, 10, Article 21658. https://doi.org/10.1038/s41598-020-78757-6

Meniscus degeneration is closely related to the progression of knee osteoarthritis (OA). However, there is currently a lack of quantitative and objective metrics to assess OA meniscal cell phenotypes. In this study we investigated the phenotypic mark... Read More about Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues.