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Outputs (135)

A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors (2021)
Thesis
Odingo, M. O. (2021). A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors. (Thesis). Keele University

Introduction A new class of lipid lowering agent Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors (PCSK9) was launched in 2015 for the treatment of heterozygous familial hypercholesterolemia (HeFH) in combination with statin therapy. There a... Read More about A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors.

Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes (2021)
Thesis
Bhunia, S. (2021). Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes. (Thesis). Keele University

The fetal membrane surrounds and supports the developing fetus during the pregnancy. The cellular structure of the fetal membrane and the proteins synthesized by the cells of amniotic and chorionic membranes, maintain the mechanical integrity of the... Read More about Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes.

Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy (2021)
Journal Article
Hulme, C. H., Peffers, M. J., Harrington, G. M. B., Wilson, E., Perry, J., Roberts, S., …Wright, K. T. (2021). Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy. American Journal of Sports Medicine, 49(6), 1512-1523. https://doi.org/10.1177/0363546521995565

Background: Biomarkers are needed to predict clinical outcomes for microfracture and osteotomy surgeries to ensure patients can be better stratified to receive the most appropriate treatment. Purpose: To identify novel biomarker candidates and to... Read More about Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy.

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors. (2021)
Journal Article
Reynisson. (2021). Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors. Molecules, https://doi.org/10.3390/molecules26071945

A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone ring condensed to C and D rings of a protoberberine core. The reaction conditions were dev... Read More about Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors..

Failed Surgery for Patellar Tendinopathy in Athletes: Midterm Results of Further Surgical Management (2021)
Journal Article
Maffulli, N., Oliva, F., Maffulli, G. D., & Migliorini, F. (2021). Failed Surgery for Patellar Tendinopathy in Athletes: Midterm Results of Further Surgical Management. Orthopaedic Journal of Sports Medicine, 9(3), https://doi.org/10.1177/2325967121994550

Background: Tendon injuries are commonly seen in sports medicine practice. Many elite players involved in high-impact activities develop patellar tendinopathy (PT) symptoms. Of them, a small percentage will develop refractory PT and need to undergo s... Read More about Failed Surgery for Patellar Tendinopathy in Athletes: Midterm Results of Further Surgical Management.

Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis (2021)
Journal Article
(2021). Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis. International Journal of Clinical Pharmacy, https://doi.org/10.1007/s11096-021-01260-z

Background Argatroban, lepirudin, desirudin, bivalirudin, and danaparoid are commonly used to manage heparin-induced thrombocytopenia related complications. However, the most suitable drug for this condition still remains controversial. Aim of the re... Read More about Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis.

Opioids for chronic low back pain management: a Bayesian network meta-analysis (2021)
Journal Article
Migliorini, F., Maffulli, N., Baroncini, A., Eschweiler, J., Tingart, M., & Quack, V. (2021). Opioids for chronic low back pain management: a Bayesian network meta-analysis. Expert Review of Clinical Pharmacology, 14(5), 635-641. https://doi.org/10.1080/17512433.2021.1903316

Introduction: Chronic low back pain (LBP) is common, and some patients require opiates therapy. This Bayesian network meta-analysis (NMA) analyzed available randomized clinical trials (RCTs) on the use of opioids for LBP. Methods: All RCTs compari... Read More about Opioids for chronic low back pain management: a Bayesian network meta-analysis.

Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier (2021)
Journal Article
Dale, T., Forsyth, N., & Maffulli, N. (2021). Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier. Pharmaceutics,

Tissue engineering strategies can be relevant for cartilage repair and regeneration. A collagen matrix was functionalized with the addition of poly-lactic-co-glycolic acid microcarriers (PLGA-MCs) carrying a human Transforming Growth Factor ß1 (hTFG-... Read More about Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier.