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Outputs (135)

Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs (2021)
Thesis
Alansari, R. H. A. (2021). Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs. (Thesis). Keele University

The human body hosts a vast number of microorganisms such as bacteria, archaea, and viruses that are colonised inside and outside the body. This combination of microorganisms living within the human body is known as microbiota. The human microbiota v... Read More about Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs.

An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. (2021)
Journal Article
Wright, K., Roberts, S., & Kuiper, J. (2021). An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, https://doi.org/10.3390/cells10081903

Chondrocyte-based cartilage repair strategies, such as articular chondrocyte implantation, are widely used, but few studies addressed the communication between native subchondral bone cells and the transplanted chondrocytes. An indirect co-culture mo... Read More about An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans..

Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions (2021)
Journal Article
Barnes, N. G., Ahmed Mal Ullah, A. A., Ragazzon, P. A., Charafi, N., & Hadfield, J. A. (2021). Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions. ChemistrySelect, 6(28), 7082 - 7086. https://doi.org/10.1002/slct.202101960

Combretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. (2021)
Journal Article
(2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model..

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. (2021)
Journal Article
Reynisson. (2021). New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. Biomolecules, https://doi.org/10.3390/biom11070973

Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-... Read More about New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition..

Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis (2021)
Journal Article
(2021). Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Crohn's & Colitis 360, https://doi.org/10.1093/crocol/otab041

Abstract Abdominal pain is a key symptom of inflammatory bowel disease (IBD), particularly in active IBD, but also occurs in patients with quiescent disease suggesting that mechanisms other than active inflammation may be responsible. Putative hypoth... Read More about Rectal Hypersensitivity in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins (2021)
Thesis
Njoroge, W. (2021). The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins. (Thesis). Keele University

Cardiovascular disease (CVD) has been identified as the leading cause of mortality in westernised society. The triggering factor for the majority of cardiovascular diseases is atherosclerosis, defined as an accumulation of fatty materials in the vasc... Read More about The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins.

Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19 (2021)
Thesis
Faux-Nightingale, A. H. (2021). Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19. (Thesis). Keele University

This project assesses the benefit that qualitative investigation of experience brings to healthcare research. It does this through: Phase One - Understanding the factors affecting AFO compliance in children with CP People with cerebral palsy (CP)... Read More about Experiences of patients and healthcare workers in the NHS pre- and post- Covid-19.

Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019) (2021)
Journal Article
Goenaga Infante, H., Warren, J., Chalmers, J., Dent, G., Todoli, J. L., Collingwood, J., …Craston, D. (2021). Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019). Pure and Applied Chemistry, 93(6), 647 - 776. https://doi.org/10.1515/pac-2019-0203

Recommendations are given concerning the terminology of concepts and methods used in spectroscopy in analytical chemistry, covering nuclear magnetic resonance spectroscopy, atomic spectroscopy, and vibrational spectroscopy.