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Outputs (102)

An evaluation of the prescribing of clozapine for treatment-resistant schizophrenia in one NHS Trust in England (2022)
Conference Proceeding
Brannen, S., Gunnell, K. A., Cooper, H., Azar, M., Campbell, A., & White, S. (2022). An evaluation of the prescribing of clozapine for treatment-resistant schizophrenia in one NHS Trust in England. . https://doi.org/10.1093/ijpp/riac019.059

Abstract
Introduction
As a merger of two trusts had occurred, and recent research on the impact of the delay of initiating clozapine (1), this study was initiated to investigate if NICE guidelines for the management of treatment-resistant schizophr... Read More about An evaluation of the prescribing of clozapine for treatment-resistant schizophrenia in one NHS Trust in England.

A novel scaffold for cell-based lung tissue engineering (2022)
Thesis
Kyoseva, A. Y. (2022). A novel scaffold for cell-based lung tissue engineering. (Thesis). Keele University

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and numbers are rising. Tissue engineering approaches have the potential to improve lung function and treat diseases such as COPD. Our aim is to investigate a... Read More about A novel scaffold for cell-based lung tissue engineering.

Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD) (2022)
Thesis
Scott, N. (2022). Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD). (Thesis). Keele University

Objectives: Observational studies of polypharmacy and the risk of death or ischaemic stroke in individuals with atrial fibrillation (AF) have produced inconsistent findings. The reason for this variation may be due to differences in study designs and... Read More about Polypharmacy in atrial fibrillation: An analysis of prospective outcomes using the Clinical Practice Research Datalink (CPRD).

Use of nanoparticles to improve the therapeutic index of navitoclax (2022)
Thesis
Alrosan, K. J. J. A. (2022). Use of nanoparticles to improve the therapeutic index of navitoclax. (Thesis). Keele University

Ovarian cancer is considered a major health problem in women. The chemotherapeutic drugs that are used often are inadequate due to the development of drug resistance. This s related to many causes, and one of them is an evasion of apoptosis. One of t... Read More about Use of nanoparticles to improve the therapeutic index of navitoclax.

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

Muscle herniae: Conservative and surgical management. Systematic review (2022)
Journal Article
Quaranta, M., Poeta, N., Oliva, F., & Maffulli, N. (2023). Muscle herniae: Conservative and surgical management. Systematic review. Surgeon, 21(3), 181-189. https://doi.org/10.1016/j.surge.2022.02.003

Background
Muscle herniae are often unrecognized. The primary objective of this systematic review is to evaluate the outcomes of conservative and surgical management for muscle herniae. The secondary objective is to define the most appropriate manag... Read More about Muscle herniae: Conservative and surgical management. Systematic review.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., …Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

<jats:p>Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improv... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA (2022)
Journal Article
Edwards-Smallbone, J., L. Jensen, A., E. Roberts, L., Isidore G. Totanes, F., Hart, S., & J. Merrick, C. (2022). Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA. Frontiers in Cellular and Infection Microbiology, 12, https://doi.org/10.3389/fcimb.2022.782537

In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures.... Read More about Plasmodium falciparum GBP2 is a telomere-associated protein that binds to G-quadruplex DNA and RNA.