Outputs (131)

Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? † (2024)
Journal Article
Besleaga, I., Raptová, R., Stoica, A.-C., Milunovic, M. N. M., Zalibera, M., Bai, R., Igaz, N., Reynisson, J., Kiricsi, M., Enyedy, É. A., Rapta, P., Hamel, E., & Arion, V. B. (in press). Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? †. Dalton Transactions, https://doi.org/10.1039/d4dt01469c

Quite recently we discovered that copper(ii) complexes with isomeric morpholine-thiosemicarbazone hybrid ligands show good cytotoxicity in cancer cells and that the molecular target responsible for this activity might be tubulin. In order to obtain b... Read More about Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization? †.

Orthobiologics Injection Therapies in the Treatment of Muscle and Tendon Disorders in Athletes: Fact or Fake? (2024)
Journal Article
Vascellari, A., Demeco, A., Vittadini, F., Gnasso, R., Tarantino, D., Belviso, I., Corsini, A., Frizziero, A., Buttinoni, L., Marchini, A., Vecchiato, M., Zappia, M., Oliva, F., Maffulli, N., Sirico, F., & Palermi, S. (in press). Orthobiologics Injection Therapies in the Treatment of Muscle and Tendon Disorders in Athletes: Fact or Fake?. M.L.T.J. Muscles, Ligaments and Tendons Journal, 14(02), 239-246. https://doi.org/10.32098/mltj.02.2024.02

Muscle and tendon injuries encompass a wide range of conditions, including both acute and chronic ailments, and are common among athletes, representing a significant cause of injuries in various sports. Frequently affected areas include the hamstring... Read More about Orthobiologics Injection Therapies in the Treatment of Muscle and Tendon Disorders in Athletes: Fact or Fake?.

The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation (2024)
Thesis
Essel, D. Y. The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849930

Augmented reality (AR) generates immersive, engaging environments that has been shown to improve learners’ motivation, knowledge and spatial awareness in some science-based subjects. Therefore, this study aimed to design, then evaluate the effectiven... Read More about The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation.

Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease (2024)
Thesis
Hassan, H. Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease. (Thesis). Keele University. https://keele-repository.worktribe.com/output/849849

Alzheimer's disease (AD) is the most common form of dementia, affecting around 26 million people worldwide, with an expected four-fold increase by 2050. It is characterized by cognitive and mental deficits and is caused by the accumulation of toxic a... Read More about Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease.

IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions? (2024)
Journal Article
Bartoli, A., Maffulli, N., Oliva, G., Ziello, S., & Oliva, F. (in press). IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions?. M.L.T.J. Muscles, Ligaments and Tendons Journal, 14(02), 361. https://doi.org/10.32098/mltj.02.2024.17

Purpose of review. The purpose of this paper is to review the current concepts regard­ing a new-old pharmacological class, SARM (Selective Androgen Receptor Modula­tor). Especially how SARM can be beneficial in treatment of orthopedic disease.
Mater... Read More about IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions?.

Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. (2024)
Journal Article
Holder, L., Yuce, E., Oriomah, G., Jenkins, A.-P., Reynisson, J., Winter, A., & Cosgrove, S. (in press). Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. ChemBioChem, 25(18), Article e202400428. https://doi.org/10.1002/cbic.202400428

Biocatalysis has played a limited role in the early stages of drug discovery. This is often attributed to the limited substrate scope of enzymes not affording access to vast areas of novel chemical space. Here, we have shown a promiscuous nitroreduct... Read More about Accessing active fragments for drug discovery utilising nitroreductase biocatalysis..

Adult-onset testosterone deficiency: the usefulness of hormone replacement in reducing mortality in men with this common age-related condition (2024)
Journal Article
Mann, A., Strange, R. C., Hackett, G., König, C., & Ramachandran, S. (2024). Adult-onset testosterone deficiency: the usefulness of hormone replacement in reducing mortality in men with this common age-related condition. Exploration of Endocrine and Metabolic Diseases, 2024(1), 83-100. https://doi.org/10.37349/eemd.2024.00010

Adult-onset testosterone deficiency (TD) in men is diagnosed by the finding of low serum testosterone levels and recognised, associated symptoms. The condition has high prevalence in men over 50 years of age, particularly those with type 2 diabetes (... Read More about Adult-onset testosterone deficiency: the usefulness of hormone replacement in reducing mortality in men with this common age-related condition.

Deciphering the Interplay: Thieno[2,3- b ]pyridine’s Impact on Glycosphingolipid Expression, Cytotoxicity, Apoptosis, and Metabolomics in Ovarian Tumor Cell Lines (2024)
Journal Article
Odak, Z., Marijan, S., Radan, M., Pilkington, L. I., Čikeš Botić, M., Barker, D., Reynisson, J., Leung, E., & Čikeš Čulić, V. (in press). Deciphering the Interplay: Thieno[2,3- b ]pyridine’s Impact on Glycosphingolipid Expression, Cytotoxicity, Apoptosis, and Metabolomics in Ovarian Tumor Cell Lines. International Journal of Molecular Sciences, 25(13), Article 6954. https://doi.org/10.3390/ijms25136954

Ovarian cancer is among the most prevalent causes of mortality among women. Despite improvements in diagnostic methods, non-specific symptoms and delayed gynecological exams can lead to late-stage ovarian tumor discovery. In this study, the effect of... Read More about Deciphering the Interplay: Thieno[2,3- b ]pyridine’s Impact on Glycosphingolipid Expression, Cytotoxicity, Apoptosis, and Metabolomics in Ovarian Tumor Cell Lines.

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology, 592,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of Theoretical Biology, Article 111874. https://doi.org/10.1016/j.jtbi.2024.111874

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation.