Outputs (15)

Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution (2021)
Journal Article

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide used in the UK as the first-line skin antiseptic prior to surgery in the UK due to its favourable efficacy and safety profile, high affinity for skin binding and minimal reports of resistance... Read More about Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution.

Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation (2020)
Journal Article

Objectives The current study aims to determine the effect of physicochemical descriptor selection on models of polydimethylsiloxane permeation. Methods A total of 2942 descriptors were calculated for a data set of 77 chemicals. Data were processed to... Read More about Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation.

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression (2018)
Journal Article

Objectives The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters. Methods Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evoluti... Read More about Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression.

Pharmacy staff perspectives on the role of community pharmacy in the provision of first aid and responding to emergencies: a qualitative study. (2017)
Presentation / Conference

No abstract

Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry (2017)
Journal Article

Abstract Skin penetration and localisation of chlorhexidine digluconate (CHG) within the skin have been investigated in order to better understand and optimise the delivery using a nano polymeric delivery system of this topically-applied antimicrobia... Read More about Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry.

Pharmacy students’ views on community pharmacy provision of first aid and responding to medical emergencies: a scenario-based questionnaire study (2016)
Presentation / Conference

Support vector regression to estimate the permeability enhancement of potential transdermal enhancers (2016)
Journal Article

Objectives Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydro... Read More about Support vector regression to estimate the permeability enhancement of potential transdermal enhancers.

Introduction (2015)
Book Chapter

This chapter describes the physiology and structure of the skin, emphasising and focusing on the skin's main barrier to permeation – the stratum corneum – and how its structure and nature, compared to other regions and layers of the skin, results in... Read More about Introduction.

Predictive Methods in Percutaneous Absorption (2015)
Book

Provides a comprehensive critique of models of percutaneous absorption, their source data and both their limitations and correct use Enriches readers’ understanding of the implications of various models Shows how to tailor models to particular... Read More about Predictive Methods in Percutaneous Absorption.