Outputs (34)

A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution (2012)
Journal Article

We present the synthesis of a novel conducting polymer (CP) incorporating both pyrrole and thiophene units in its monomer, which is also substituted with an initiator for grafting of sidechains by atom-transfer radical polymerisation (ATRP). The prec... Read More about A new precursor for conducting polymer-based brush interfaces with electroactivity in aqueous solution.

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity (2012)
Journal Article

A pyrazolo-pyrimidinone based series of growth hormone secretagogue receptor type 1a (GHS-R1a) antagonists and inverse agonists were identified using a scaffold hop from known quinazolinone GHS-R1a modulators. Lipophilicity was reduced to decrease hE... Read More about Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity.

Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis (2012)
Journal Article

Gene delivery technologies to introduce foreign genes into highly differentiated mammalian cells have improved significantly over the last few decades. Relatively new techniques such as magnetic nanoparticle-based gene transfection technology are sho... Read More about Delivery of short interfering ribonucleic acid-complexed magnetic nanoparticles in an oscillating field occurs via caveolae-mediated endocytosis.

Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice (2012)
Journal Article

Meal feeding is a critical issue in the over-consumption of calories leading to human obesity. To investigate the mechanisms involved in the regulation of meal feeding in rodents, we studied a scheduled feeding regime that induces substantial food in... Read More about Arcuate Nucleus Homeostatic Systems are Not Altered Immediately Prior to the Scheduled Consumption of Large, Binge-Type Meals of Palatable Solid or Liquid Diet in Rats and Mice.

Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study (2012)
Journal Article

BACKGROUND: Non-adherence to prescribed medication is a pervasive problem that can incur serious effects on patients' health outcomes and well-being, and the availability of resources in healthcare systems. This study aimed to develop practical conse... Read More about Developing consensus-based policy solutions for medicines adherence for Europe: a Delphi study.

Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells (2012)
Journal Article

DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems (2012)
Journal Article

Mitomycin C is a DNA alkylating agent activated by bioreduction. It has been in clinical use against a range of solid tumours since the 1960s. Its DNA adduct formation mechanism has been extensively studied and it therefore presents an excellent test... Read More about DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems.

Atrial fibrillation in heart failure: an innocent bystander? (2012)
Journal Article

Heart failure (HF) and atrial fibrillation (AF) frequently coexist and each complicates the course of the other. The purpose of this review is to analyse the prognostic impact of AF in patients with HF and assess whether there is an advantage in targ... Read More about Atrial fibrillation in heart failure: an innocent bystander?.

Student perceptions of the progress test in two settings and the implications for test deployment (2012)
Journal Article

Background The Progress Test (PT) was developed to assess student learning within integrated curricula. Whilst it is effective in promoting and rewarding deep approaches to learning in some settings, we hypothesised that implementation of the curricu... Read More about Student perceptions of the progress test in two settings and the implications for test deployment.

Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model (2012)
Journal Article

Our previous studies have shown that both lung cancer cells and non-malignant lung cells release acetaldehyde in vitro. However, data from other laboratories have produced conflicting results. Furthermore, all these studies have been carried out in 2... Read More about Quantification by SIFT-MS of acetaldehyde released by lung cells in a 3D model.