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Outputs (139)

Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons. (2020)
Journal Article

Background: Pulvertaft Weave (PTW) is an established method of tenorrhapy in tendon transfers. Previous studies have suggested that a Side-to-Side (STS) tenorrhapy is easier to perform has the same advantages and has greater load to failure, ultimate... Read More about Biomechanical Evaluation Comparing Pulvertaft Weave and Side-to-Side Tenorrhaphy Using Porcine Tendons..

The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation (2020)
Thesis

Introduction Patients commencing new medications, particularly those that are high risk such as non-vitamin K oral anticoagulants (NOACs), require counselling to ensure safe, effective and empowering use of the medicine. Pharmacists are well placed... Read More about The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation.

Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex (2020)
Thesis

Projection neurons located in the superficial layers of the entorhinal cortex provide the hippocampus with nearly all its sensory input. This innervation occurs via multiple discrete pathways to different targets within the hippocampus, including the... Read More about Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex.

Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. (2020)
Journal Article

BACKGROUND: Primary embryonic ventral mesencephalic (VM) cultures are a high throughput tool for understanding and manipulating dopamine neurons, to study the mechanisms that trigger their degeneration during Parkinson's disease (PD), and to test new... Read More about Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons..

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues (2020)
Journal Article

Meniscus degeneration is closely related to the progression of knee osteoarthritis (OA). However, there is currently a lack of quantitative and objective metrics to assess OA meniscal cell phenotypes. In this study we investigated the phenotypic mark... Read More about Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues.

An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs. (2020)
Journal Article

BACKGROUND: Popeye domain-containing proteins 1 and 2 (POPDC1 and POPDC2) are transmembrane proteins involved in cyclic AMP-mediated signalling processes and are required for normal cardiac pacemaking and conduction. In order to identify novel protei... Read More about An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs..