Outputs (64)

Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice (2013)
Journal Article
Pryde, D. C., Jones, L. H., Gervais, D. P., Stead, D. R., Blakemore, D. C., Selby, M. D., …McCluskie, M. J. (2013). Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. PloS one, 8(10), Article e76557. https://doi.org/10.1371/journal.pone.0076557

Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab function depends on both the quantity (titer) and the quality (affinity)... Read More about Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice.

Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion (2013)
Journal Article
Takemoto, N., Suehara, T., Frisco, H. L., Sato, S., Sezaki, T., Kusamori, K., …Uesugi, M. (2013). Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion. Journal of the American Chemical Society, 135(30), 11032 -11039. https://doi.org/10.1021/ja4018682

Adhesamine is an organic small molecule that promotes adhesion and growth of cultured human cells by binding selectively to heparan sulfate on the cell surface. The present study combined chemical, physicochemical, and cell biological experiments, us... Read More about Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion.

Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies (2013)
Journal Article
Hansen, S. U., Miller, G. J., Cole, C., Rushton, G., Avizienyte, E., Jayson, G. C., & Gardiner, J. M. (2013). Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nature communications, 4, Article 2016. https://doi.org/10.1038/ncomms3016

Heparin-like oligosaccharides mediate numerous important biological interactions, of which many are implicated in various diseases. Synthetic improvements are central to the development of such oligosaccharides as therapeutics and, in addition, there... Read More about Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies.

First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide (2012)
Journal Article
Hansen, S. U., Miller, G. J., Jayson, G. C., & Gardiner, J. M. (2013). First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide. Organic Letters, 15(1), 88 - 91. https://doi.org/10.1021/ol303112y

The first example of a gram-scale synthesis of a structurally defined, heparin-related dodecasaccharide is reported. An iterative 14-step process using an iduronate donor disaccharide delivers >1g quantities of the dodecasaccharide sequence [GlcNS-Id... Read More about First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide.