Outputs (5)

Prospects for anti-Candida therapy through targeting the cell wall: A mini-review (2021)
Journal Article
Ahmadipour, S., Field, R. A., & Miller, G. (2021). Prospects for anti-Candida therapy through targeting the cell wall: A mini-review. The Cell Surface, 7, Article 100063. https://doi.org/10.1016/j.tcsw.2021.100063

The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment, despite ever-increasing incidence exacerbated by an increased incidence of immunocompromised indi... Read More about Prospects for anti-Candida therapy through targeting the cell wall: A mini-review.

Synthetic Strategies for FRET-Enabled Carbohydrate Active Enzyme Probes (2021)
Book Chapter
Singh, M., Watkinson, M., Scanlan, E. M., & Miller, G. J. (2021). Synthetic Strategies for FRET-Enabled Carbohydrate Active Enzyme Probes. In Glycosylation Methods and Protocols (237-264). (1). https://doi.org/10.1007/978-1-0716-1685-7_12

Developments in the Chemical Synthesis of Heparin and Heparan Sulfate (2021)
Journal Article
Pongener, I., O'Shea, C., Wootton, H., Watkinson, M., & Miller, G. J. (2021). Developments in the Chemical Synthesis of Heparin and Heparan Sulfate. Chemical Record, 21(11), 3238-3255. https://doi.org/10.1002/tcr.202100173

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological importance. As such, their efficiency of synthesis represents a key requirement, to further underst... Read More about Developments in the Chemical Synthesis of Heparin and Heparan Sulfate.

Chemical synthesis of C6-tetrazole ?-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate (2021)
Journal Article
Miller, G., & Dimitriou, E. (2021). Chemical synthesis of C6-tetrazole ?-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate. Beilstein Journal of Organic Chemistry, 1527 - 1532. https://doi.org/10.3762/bjoc.17.110

Alginate is a biocompatible and industrially relevant polysaccharide that derives many of its important properties from the charged carboxylate groups within its polyuronic acid backbone. The design and inclusion of isosteric replacements for these c... Read More about Chemical synthesis of C6-tetrazole ?-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate.

Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1 (2021)
Journal Article
Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Guimond, S. E., Procter, P., Guerrini, M., …Skidmore, M. A. (2021). Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1. Marine Drugs, 19(4), 203 -203. https://doi.org/10.3390/md19040203

Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years. The widely used clinical anticoagulant heparin has been reported to exert beneficial effects t... Read More about Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease ß Secretase, BACE1.