Developments in the Chemical Synthesis of Heparin and Heparan Sulfate
Pongener, Imlirenla; O'Shea, Conor; Wootton, Hannah; Watkinson, Michael; Miller, Gavin J.
Gavin Miller firstname.lastname@example.org
Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological importance. As such, their efficiency of synthesis represents a key requirement, to further understand and exploit the H/HS structure-to-biological function axis. In this review we focus on chemical approaches to and methodology improvements for the synthesis of these essential sugars (from 2015 onwards). We first consider advances in accessing the heparin-derived pentasaccharide anticoagulant fondaparinux. This is followed by heparan sulfate targets, including key building block synthesis, oligosaccharide construction and chemical sulfation techniques. We end with a consideration of technological improvements to traditional, solution-phase synthesis approaches that are increasingly being utilised.
|Journal Article Type
|Sep 15, 2021
|Online Publication Date
|Sep 15, 2021
|Publicly Available Date
|May 30, 2023
|The Chemical Record
|Materials Chemistry, General Chemical Engineering, Biochemistry, General Chemistry
Publisher Licence URL
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