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Biocatalytic Nucleobase Diversification of 4'-Thionucleosides and Application of Derived 5-Ethynyl-4'-thiouridine for RNA synthesis detection. (2024)
Journal Article
Westarp, S., Benckendorff, C., Motter, J., Rohrs, V., Sanghvi, Y., Neubauer, P., …Miller, G. J. (in press). Biocatalytic Nucleobase Diversification of 4'-Thionucleosides and Application of Derived 5-Ethynyl-4'-thiouridine for RNA synthesis detection. Angewandte Chemie, Article e202405040. https://doi.org/10.1002/anie.202405040

Nucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections and cancer. One branch of structural modification to deliver new nucleoside analogue classes explores replacement of canonical ribose oxygen wit... Read More about Biocatalytic Nucleobase Diversification of 4'-Thionucleosides and Application of Derived 5-Ethynyl-4'-thiouridine for RNA synthesis detection..

Biocatalytic Nucleobase Diversification of 4'‐Thionucleosides and Application of Derived 5‐Ethynyl‐4'‐thiouridine for RNA synthesis detection (2024)
Journal Article
Westarp, S., Benckendorff, C., Motter, J., Rohrs, V., Sanghvi, Y., Neubauer, P., …Miller, G. J. (in press). Biocatalytic Nucleobase Diversification of 4'‐Thionucleosides and Application of Derived 5‐Ethynyl‐4'‐thiouridine for RNA synthesis detection. Angewandte Chemie, Article e202405040. https://doi.org/10.1002/ange.202405040

Nucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections and cancer. One branch of structural modification to deliver new nucleoside analogue classes explores replacement of canonical ribose oxygen wit... Read More about Biocatalytic Nucleobase Diversification of 4'‐Thionucleosides and Application of Derived 5‐Ethynyl‐4'‐thiouridine for RNA synthesis detection.

Synthesis of a heparan sulfate tetrasaccharide using automated glycan assembly † (2024)
Journal Article
Pongener, I., Sletten, E. T., Danglad-Flores, J., Seeberger, P. H., & Miller, G. J. (in press). Synthesis of a heparan sulfate tetrasaccharide using automated glycan assembly †. Organic and Biomolecular Chemistry, https://doi.org/10.1039/d3ob01909h

Herein we utilise automated glycan assembly to complete solid-phase synthesis of defined heparan sulfate oligosaccharides, employing challenging d-glucuronate disaccharide donors. Using an orthogonally protected d-GlcN-α-d-GlcA donor, milligram-scale... Read More about Synthesis of a heparan sulfate tetrasaccharide using automated glycan assembly †.

Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology (2024)
Journal Article
Motter, J., Benckendorff, C. M. M., Westarp, S., Sunde-Brown, P., Neubauer, P., Kurreck, A., & Miller, G. J. (in press). Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology. Natural Product Reports, https://doi.org/10.1039/d3np00051f

Covering: 2019 to 2023 Nucleoside analogues represent one of the most important classes of small molecule pharmaceuticals and their therapeutic development is successfully established within oncology and for the treatment of viral infections. However... Read More about Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology.

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., …Cosgrove, S. C. (2023). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300752. https://doi.org/10.1002/cbic.202300752

Wahart et al. demonstrate the use of an immobilised oxidase enzyme coupled to an extractive amino resin for the bioremediation of a common industrial surfactant. This allows the facile purification of alkyl monoglucosides without the need for high en... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides.

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. (2023)
Journal Article
Hoolachan, J. M., McCallion, E., Sutton, E. R., Çetin, Ö., Pacheco-Torres, P., Dimitriadi, M., …Bowerman, M. (2023). A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. Human molecular genetics, ddad192. https://doi.org/10.1093/hmg/ddad192

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation therapies are clinically approved that significantly slow down disease progres... Read More about A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models..

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., …Cosgrove, S. C. (in press). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300625. https://doi.org/10.1002/cbic.202300625

As the world moves towards net-zero carbon emissions, the development of sustainable chemical manufacturing processes is essential. Within manufacturing, purification by distillation is often used, however this process is energy intensive and methods... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides..

Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library † (2023)
Journal Article
Keenan, T., Hatton, N. E., Porter, J., Vendeville, J., Wheatley, D. E., Ghirardello, M., …Fascione, M. A. (in press). Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library †. Chemical Science, 14(42), 11638-11646. https://doi.org/10.1039/d3sc04169g

β-Mannosides are ubiquitous in nature, with diverse roles in many biological processes. Notably, Manβ1,4GlcNAc a constituent of the core N-glycan in eukaryotes was recently identified as an immune activator, highlighting its potential for use in immu... Read More about Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library †.

Preparation of a 4′‐Thiouridine Building‐Block for Solid‐Phase Oligonucleotide Synthesis (2023)
Journal Article
Benckendorff, C. M. M., Sanghvi, Y. S., & Miller, G. J. (2023). Preparation of a 4′‐Thiouridine Building‐Block for Solid‐Phase Oligonucleotide Synthesis. Current Protocols in Neuroscience, 3(9), e878. https://doi.org/10.1002/cpz1.878

Starting from a commercially available thioether, we report a nine‐step synthesis of a 4′‐thiouridine phosphoramidite building‐block. We install the uracil nucleobase using Pummerer‐type glycosylation of a sulfoxide intermediate followed by a series... Read More about Preparation of a 4′‐Thiouridine Building‐Block for Solid‐Phase Oligonucleotide Synthesis.