Outputs (5)

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases (2020)
Journal Article
Mangas-Sanchez, J., Sharma, M., Cosgrove, S. C., Ramsden, J. I., Marshall, J. R., Thorpe, T. W., …Turner, N. J. (in press). Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chemical Science, 11(19), 5052-5057. https://doi.org/10.1039/d0sc02253e

Chiral primary amines are important intermediates in the synthesis of pharmaceutical compounds. Fungal reductive aminases (RedAms) are NADPH-dependent dehydrogenases that catalyse reductive amination of a range of ketones with short-chain primary ami... Read More about Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases.

Is it time for biocatalysis in fragment-based drug discovery? (2020)
Journal Article
Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature... Read More about Is it time for biocatalysis in fragment-based drug discovery?.

One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation. (2020)
Journal Article
Cosgrove. (2020). One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation. Angewandte Chemie, 18156 - 18160. https://doi.org/10.1002/anie.202006246

The combination of biocatalysis and chemo-catalysis increasingly offers chemists access to more diverse chemical architectures. Here, we describe the combination of a toolbox of chiral-amine-producing biocatalysts with a Buchwald-Hartwig cross-coupli... Read More about One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation..

Natural heterogeneous catalysis with immobilised oxidase biocatalysts (2020)
Journal Article
Mattey, A. P., Sangster, J. J., Ramsden, J. I., Baldwin, C., Birmingham, W. R., Heath, R. S., …Flitsch, S. L. (in press). Natural heterogeneous catalysis with immobilised oxidase biocatalysts. RSC advances, 10(33), 19501-19505. https://doi.org/10.1039/d0ra03618h

The generation of immobilised oxidase biocatalysts allowing multifunctional oxidation of valuable chemicals using molecular oxygen is described. Engineered galactose oxidase (GOase) variants M1 and M3–5, an engineered choline oxidase (AcCO6) and mono... Read More about Natural heterogeneous catalysis with immobilised oxidase biocatalysts.

Rapid Model-Based Optimization of a Two-Enzyme System for Continuous Reductive Amination in Flow (2020)
Journal Article
Finnigan, W., Citoler, J., Cosgrove, S. C., & Turner, N. J. (2020). Rapid Model-Based Optimization of a Two-Enzyme System for Continuous Reductive Amination in Flow. Organic Process Research and Development, 24(10), 1969-1977. https://doi.org/10.1021/acs.oprd.0c00075

Enzymes are increasingly combined into multienzyme systems for cost and productivity benefits. Further advantages can be gained through the use of immobilized enzymes, allowing continuous biotransformations in flow. However, the optimization of such... Read More about Rapid Model-Based Optimization of a Two-Enzyme System for Continuous Reductive Amination in Flow.