Is it time for biocatalysis in fragment-based drug discovery?

Cosgrove

Abstract

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.

Citation

Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

• Acceptance Date: Oct 7, 2020
• Publication Date: Nov 7, 2020
• Journal: Chemical Science
• Print ISSN: 2041-6520
• Publisher: Royal Society of Chemistry
• Pages: 11104 - 11112
• DOI: https://doi.org/10.1039/D0SC04103C
• Keywords: fragment-based drug discovery, biocatalysis, chemistry
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2020/SC/D0SC04103C#!divAbstract