PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2
(2018)
Journal Article
Desbois, M., Crawley, O., Evans, P. R., Baker, S. T., Masuho, I., Yasuda, R., & Grill, B. (2018). PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. Journal of biological chemistry, 293(36), 13897-13909. https://doi.org/10.1074/jbc.ra118.002176
PHR (PAM/Highwire/RPM-1) proteins are conserved RING E3 ubiquitin ligases that function in developmental processes, such as axon termination and synapse formation, as well as axon degeneration. At present, our understanding of how PHR proteins form u... Read More about PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.