Outputs (6)

Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration (2025)
Journal Article
Dube, C. T., Gilbert, H. T. J., Rabbitte, N., Baird, P., Patel, S., Herrera, J. A., Baricevic-Jones, I., Unwin, R. D., Chan, D., Gnanalingham, K., Hoyland, J. A., & Richardson, S. M. (2025). Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration. Arthritis Research and Therapy, 27(1), Article 28. https://doi.org/10.1186/s13075-025-03489-9

Background: Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. Current techniques used to diagnose IVD degeneration, suc... Read More about Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration.

Transcriptomic profiling reveals key early response genes during GDF6‐mediated differentiation of human adipose‐derived stem cells to nucleus pulposus cells (2024)
Journal Article
Gilbert, H. T. J., Wignall, F. E. J., Zeef, L., Hoyland, J. A., & Richardson, S. M. (2024). Transcriptomic profiling reveals key early response genes during GDF6‐mediated differentiation of human adipose‐derived stem cells to nucleus pulposus cells. JOR Spine, 7(1), Article 1315. https://doi.org/10.1002/jsp2.1315

Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells (2023)
Journal Article
Llewellyn, J., Mallikarjun, V., Gilbert, H., Richardson, S., Hubbard, S., Swift, J., Appleton, E., & Osipova, M. (2023). Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells. Proceedings of the National Academy of Sciences of the United States of America, https://doi.org/10.1073/pnas.2210745120

<jats:p>Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of prot... Read More about Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells.

Acidic PH inhibits the stiffness response in human bone marrow mesenchymal stem cells (BM-MSCS) (2023)
Journal Article
Usta, Y., Lawless, C., Swift, J., Richardson, S., & Gilbert, H. (2023). Acidic PH inhibits the stiffness response in human bone marrow mesenchymal stem cells (BM-MSCS). International Journal of Clinical and Experimental Pathology, A19 - A19. https://doi.org/10.1111/iep.12471

Acidic pH inhibits the stiffness response of human bone-marrow mesenchymal stem cells (BM-MSCs) (2023)
Presentation / Conference
Hakan Usta, Y., Swift, J., Gilbert, H. T., & Richardson, S. M. (2023, March). Acidic pH inhibits the stiffness response of human bone-marrow mesenchymal stem cells (BM-MSCs). Presented at TERMIS 2023 – European Chapter, Manchester Central Conference Centre Manchester, UK

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence (2022)
Journal Article
Mallikarjun, V., Dobre, O., Jackson, M., Kidd, M., Llewellyn, J., Gilbert, H., Richardson, S., & Swift, J. (2022). Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence. arXiv,

ABSTRACT Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche exp... Read More about Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence.