Outputs (22)

Crystal structures of human SP-D complexed with synthetic oligosaccharides suggest a role for phosphorylated inner core LPS saccharides in host-pathogen interactions (2025)
Preprint / Working Paper
Williams, H. M., Watson, A., Madsen, J., Clark, H. W., Hood, D. W., Oscarson, S., Greenhough, T. J., & Shrive, A. K. (2025). Crystal structures of human SP-D complexed with synthetic oligosaccharides suggest a role for phosphorylated inner core LPS saccharides in host-pathogen interactions

The innate immune protein human surfactant protein D (SP-D) recognises pathogens in the lungs via binding to carbohydrate surface structures. SP-D has been shown to target gram-negative bacterial lipopolysaccharide via calcium-dependent binding, pref... Read More about Crystal structures of human SP-D complexed with synthetic oligosaccharides suggest a role for phosphorylated inner core LPS saccharides in host-pathogen interactions.

Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs (2023)
Journal Article
Williams, H. M., Moeller, J. B., Burns, I., Schlosser, A., Sorensen, G. L., Greenhough, T. J., Holmskov, U., & Shrive, A. K. (2023). Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs. Journal of Biological Chemistry, 105552. https://doi.org/10.1016/j.jbc.2023.105552

Fibrinogen C-domain containing-1 (FIBCD1) is an immune protein proposed to be involved in host recognition of chitin on the surface of pathogens. As FIBCD1 readily binds to acetylated molecules, we have determined the high-resolution crystal structur... Read More about Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs.

Characterisation of the Structural Requirements for the Immunomodulatory Surfactant Protein D (SP-D) to Bind to Maltose Based Ligands (2022)
Presentation / Conference Contribution
Shrive, & Greenhough. (2022, May). Characterisation of the Structural Requirements for the Immunomodulatory Surfactant Protein D (SP-D) to Bind to Maltose Based Ligands. Poster presented at American Thoracic Society International Conference, Moscone Center, San Francisco, California

Structural studies of C-reactive protein (2021)
Presentation / Conference Contribution
Collister, S., Neale, W., Littlejohn, J., Greenhough, T., & Shrive, A. (2021, August). Structural studies of C-reactive protein. Poster presented at XXV IUCr Congress, Prague, Czech Republic

Bacterial lipopolysaccharide recognition by surfactant protein D (2021)
Presentation / Conference Contribution
Shrive, & Greenhough. (2021, August). Bacterial lipopolysaccharide recognition by surfactant protein D. Presented at XXV IUCr Congress, Prague, Czech Republic

Human surfactant protein D is a collectin and member of the C-type lectin superfamily of proteins that forms an essential part of the mammalian innate immune system. The collectins have been recognised to not only bind to invading pathogens, allowing... Read More about Bacterial lipopolysaccharide recognition by surfactant protein D.

Lipopolysaccharide recognition by human surfactant protein D (2021)
Presentation / Conference Contribution
Neale, W., Madsen, J., Clark, H., Shrive, A., & Greenhough, T. (2021, August). Lipopolysaccharide recognition by human surfactant protein D. Poster presented at XXV IUCr Congress, Prague, Czech Republic

Structural studies of innate immune proteins (2021)
Presentation / Conference Contribution
da Silva, R., Burns, I., Greenhough, T. J., & Shrive, A. K. (2021, August). Structural studies of innate immune proteins. Poster presented at XXV IUCr Congress, Prague, Czech Republic

X-ray diffraction data for structure associated with PDB ID: 6ZQX (2020)
Data
Shrive, A., & Greenhough, T. (2020). X-ray diffraction data for structure associated with PDB ID: 6ZQX. [Data]. https://doi.org/10.21252/2b3f-9369

X-ray diffraction data for structure associated with PDB ID: 6ZR0 (2020)
Data
Shrive, A., & Greenhough, T. (2020). X-ray diffraction data for structure associated with PDB ID: 6ZR0. [Data]. https://doi.org/10.21252/zcfy-cw20

X-Ray diffraction data for structure associated with PDB ID: 6ZQY (2020)
Data
Shrive, A., & Greenhough, T. (2020). X-Ray diffraction data for structure associated with PDB ID: 6ZQY. [Data]. https://doi.org/10.21252/hx7e-rd04