Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England

Freeman, Karoline; Jenkinson, David; Clements, Karen; Wallis, Matthew G; Pinder, Sarah E; Provenzano, Elena; Stobart, Hilary; Stallard, Nigel; Kearins, Olive; Sharma, Nisha; Shaaban, Abeer; Kirwan, Cliona Clare; Hilton, Bridget; Thompson, Alastair M; Taylor-Phillips, Sian

Abstract

Objective To explore how the number and type of breast cancers developed after screen detected atypia compare with the anticipated 11.3 cancers detected per 1000 women screened within one three year screening round in the United Kingdom.

Design Observational analysis of the Sloane atypia prospective cohort in England.

Setting Atypia diagnoses through the English NHS breast screening programme reported to the Sloane cohort study. This cohort is linked to the English Cancer Registry and the Mortality and Birth Information System for information on subsequent breast cancer and mortality.

Participants 3238 women diagnosed as having epithelial atypia between 1 April 2003 and 30 June 2018.

Main outcome measures Number and type of invasive breast cancers detected at one, three, and six years after atypia diagnosis by atypia type, age, and year of diagnosis.

Results There was a fourfold increase in detection of atypia after the introduction of digital mammography between 2010 (n=119) and 2015 (n=502). During 19 088 person years of follow-up after atypia diagnosis (until December 2018), 141 women developed breast cancer. Cumulative incidence of cancer per 1000 women with atypia was 0.95 (95% confidence interval 0.28 to 2.69), 14.2 (10.3 to 19.1), and 45.0 (36.3 to 55.1) at one, three, and six years after atypia diagnosis, respectively. Women with atypia detected more recently have lower rates of subsequent cancers detected within three years (6.0 invasive cancers per 1000 women (95% confidence interval 3.1 to 10.9) in 2013-18 v 24.3 (13.7 to 40.1) in 2003-07, and 24.6 (14.9 to 38.3) in 2008-12). Grade, size, and nodal involvement of subsequent invasive cancers were similar to those of cancers detected in the general screening population, with equal numbers of ipsilateral and contralateral cancers.

Conclusions Many atypia could represent risk factors rather than precursors of invasive cancer requiring surgery in the short term. Women with atypia detected more recently have lower rates of subsequent cancers detected, which might be associated with changes to mammography and biopsy techniques identifying forms of atypia that are more likely to represent overdiagnosis. Annual mammography in the short term after atypia diagnosis might not be beneficial. More evidence is needed about longer term risks.

Citation

Freeman, K., Jenkinson, D., Clements, K., Wallis, M. G., Pinder, S. E., Provenzano, E., …Taylor-Phillips, S. (in press). Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England. BMJ, Article 384. https://doi.org/10.1136/bmj-2023-077039

• Journal Article Type: Article
• Acceptance Date: Nov 22, 2023
• Online Publication Date: Feb 1, 2024
• Deposit Date: Dec 20, 2024
• Publicly Available Date: Dec 20, 2024
• Journal: BMJ
• Print ISSN: 0959-8138
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Article Number: 384
• DOI: https://doi.org/10.1136/bmj-2023-077039
• Public URL: https://keele-repository.worktribe.com/output/1020021
• Publisher URL: https://www.bmj.com/content/384/bmj-2023-077039