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Outputs (5093)

Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy (2024)
Thesis
Çetin, Ö. (2024). Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853197

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by the loss-of-function of the survival motor neuron (SMN) gene resulting in muscle atrophy and weakness. There are currently 3 gene-based therapies (Spinraza®, Zolgensma® and Evrysdi®)... Read More about Investigating the therapeutic potential of repurposed drugs that target central nervous system and peripheral pathologies in cellular and animal models of spinal muscular atrophy.

Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles (2024)
Thesis
Fernando, B. L. (2024). Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/855660

Introduction Patients with medically unexplained symptoms (MUS), i.e., physical complaints not fully explained by somatic/psychiatric pathology, are well-documented as a significant problem in primary care. Yet, the issues these patients and their... Read More about Towards an ethically informed framework for managing patients with medically unexplained symptoms: developing boundary principles.

Optimising physiotherapy treatment for people with lateral elbow tendinopathy: development and pilot/feasibility testing of an evidence-based treatment approach (2024)
Thesis
Bateman, M. (2024). Optimising physiotherapy treatment for people with lateral elbow tendinopathy: development and pilot/feasibility testing of an evidence-based treatment approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853496

Background: There are a wide range of physiotherapy treatment options for people with lateral elbow tendinopathy (LET), however previous studies have reported inconsistent approaches to treatment and a lack of evidence demonstrating clinical effectiv... Read More about Optimising physiotherapy treatment for people with lateral elbow tendinopathy: development and pilot/feasibility testing of an evidence-based treatment approach.

How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress? (2024)
Thesis
Awan, H. How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress?. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849807

People with physical-mental comorbidity have a poorer quality of life, worse clinical outcomes and increased mortality than those with physical conditions alone. Those from some ethnic groups may be less likely to recognise and seek help for symptoms... Read More about How do males of South Asian origin with long-term physical conditions understand, experience and seek help for emotional distress?.

Healthcare practitioners' views of self‐harm management practices in older adults in Ireland: A qualitative study (2024)
Journal Article
Troya, M. I., Lonergan, C., Cassidy, E., Griffin, E., Lovejoy, S. A., Mughal, F., …Arensman, E. (2024). Healthcare practitioners' views of self‐harm management practices in older adults in Ireland: A qualitative study. International Journal of Geriatric Psychiatry, 39(7), Article e6116. https://doi.org/10.1002/gps.6116

Objectives: To explore healthcare practitioners' views on management practices of self‐harm in older adults. Methods: Semi‐structured interviews were conducted with healthcare practitioners, including consultant psychiatrists, general practitioners,... Read More about Healthcare practitioners' views of self‐harm management practices in older adults in Ireland: A qualitative study.

Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis (2024)
Journal Article
Echrish, J., Pasca, M.-I., Cabrera, D., Yang, Y., & Harper, A. G. S. (2024). Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis. Biomimetics, 9(6), Article 372. https://doi.org/10.3390/biomimetics9060372

Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen... Read More about Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis.

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary: Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences (2024)
Journal Article
Zaheer, A., Qiu, F., Manoragavan, R., Madan, M., Sud, M., Mamas, M. A., & Wijeysundera, H. C. (2024). Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences. Journal of the American Heart Association, 13(12), https://doi.org/10.1161/jaha.123.032450

Background Transcatheter aortic valve replacement (TAVR) has become the standard of care for severe aortic stenosis treatment. Exponential growth in demand has led to prolonged wait times and adverse patient outcomes. Social marginalization may contr... Read More about Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences.

The potential of point-of-care ultrasound in UK general practice (2024)
Journal Article
Poppleton, A., Pursglove, L., Leceaga, E., Dupont, F., Hagiu, D.-P., & Andersen, C. (in press). The potential of point-of-care ultrasound in UK general practice. InnovAiT: Education and inspiration for general practice, https://doi.org/10.1177/17557380241257451

Ultrasound has been described as the stethoscope for the 21st century. It can rapidly answer a specific clinical question or support a procedure. Use of point-of-care ultrasound (PoCUS) by doctors has increased in the UK and internationally over the... Read More about The potential of point-of-care ultrasound in UK general practice.