Circular RNAs in the management of human osteoporosis.

Gargano, Giuseppe; Pagano, Simona M; Maffulli, Nicola

Abstract

Osteoporosis (OP) is a metabolic bone disease producing reduction in bone mass with consequent bone fragility. Circular ribonucleic acid (CircRNA) is a form of RNA that forms a loop structure rather than a linear one. CircRNA can be used for therapeutic purposes, including molecular targets or to test new therapies. A systematic search of different databases to July 2024 was performed to define the role of circRNA in OP therapy. Seventeen suitable studies were identified. CircRNAs may be useful in studying metabolic processes in OP and identify possible therapeutic targets and new drug therapies. The metabolic processes involved in OP are regulated by many genes and cytokines that can be targeted by CircRNAs. However, it is not easy to predict whether the in vitro responses of the studied CircRNAs and their interaction with drugs are also applicable in vivo. Metabolic processes can be affected by gene dysregulation of CircRNAs on various growth factors. Areas timely for developing research: Despite the predictability of CircRNA pharmacological response in vitro, such pharmacological response cannot be expected to be replicated in vivo. The data that support the findings of this study are available from the corresponding author. [Abstract copyright: © The Author(s) 2025. Published by Oxford University Press. All rights reserved. For Permissions, please email: [e-mail].]

Citation

Gargano, G., Pagano, S. M., & Maffulli, N. (2025). Circular RNAs in the management of human osteoporosis. British Medical Bulletin, 153(1), https://doi.org/10.1093/bmb/ldae024

• Journal Article Type: Article
• Acceptance Date: Dec 15, 2024
• Online Publication Date: Jan 16, 2025
• Publication Date: Jan 16, 2025
• Deposit Date: Mar 19, 2025
• Journal: British medical bulletin
• Print ISSN: 0007-1420
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 153
• Issue: 1
• DOI: https://doi.org/10.1093/bmb/ldae024
• Keywords: ribonucleic acid silencing, osteoporosis therapy, RNA, Circular - genetics, Osteoporosis - genetics - therapy - metabolism, Humans, osteoporosis, circular ribonucleic acid, ribonucleic acid interference
• Public URL: https://keele-repository.worktribe.com/output/1053595
• Publisher URL: https://academic.oup.com/bmb/article/153/1/ldae024/7958569